吸毒成瘾者免疫功能变化的研究  

Alterations of immune functions in heroin addicts

作　　者：张明[1] 闫燕华[1] 毛利群[1] 尹伯元 张广福 张国庆 

机构地区：[1]天津医科大学免疫教研室 [2]天津津成放免中心 [3]天津市戒毒所

出　　处：《天津医科大学学报》2000年第4期380-382,共3页Journal of Tianjin Medical University

摘　　要：目的 :测定吸毒者体液免疫和细胞免疫的各项指标 ,从而研究其免疫功能的改变。方法 :取25例吸毒者及28例健康成人外周血 ,用ELISA法和免疫比浊法测其血清中抗体和补体 ;免疫荧光法和酶联免疫斑点法 (ELISPOT)测其T细胞亚群和Th细胞亚群。结果 :吸毒者IgG增高 ,C3 下降 ,IgA、IgM和IgE与正常人无显著差异。吸毒者CD3、CD4、CD4/CD8、Th1 和Th1/Th2 低于正常人 ,而CD8、CD20 和Th2 与正常人相差不大。淋巴细胞转化试验吸毒者显著低于正常对照组。结论 :吸毒者细胞免疫功能降低 。Objective: To study the alterations of immune functions in drug addicts through measurement of humoral and cellular immunity. Methods: IgG, IgM, IgA and C3 were determined by turbidimetric immunoassay, IgE were determined by ELISA in sera of 25 patients and 28 controls. T cell subsets were determined by immunofluorescence and T-helper cell subsets were determined by ELISPOT. Lymphocyte proliferation assay was also used to assess cellular immunity. Results: There was no statistical difference between the two groups of IgA, IgM and IgE, except a higher level of IgG and a lower level of C3 in drug addicts. The percentages of CD3, CD4, Th1 and the ratio of CD4/ CD8 and Th1/Th2 in drug addicts were lower than those of controls, while the percentages of CD8, CD20 and Th2 were nearly the same between the two groups; and drugs inhibited lymphocyte proliferation.Conclusion: Drug abuse can impair the celluar immunity, but has little effects on the humoral immunity.

关 键 词：吸毒成瘾者 免疫功能 辅助性T细胞(Th) 

分 类 号：R392.12[医药卫生—免疫学]