急性大出血及不同液体容量复苏对犬血清S100B蛋白的影响  

Effects of acute massive haemorrhage and fluid resuscitation on serum S100B protein in dogs

作　　者：倪玉霞[1] 谭冠先[1] 江朝秀[1] 潘敬禧[1] 

机构地区：[1]广西医科大学第一附属医院麻醉科,南宁市530021

出　　处：《临床麻醉学杂志》2005年第1期44-46,共3页Journal of Clinical Anesthesiology

基　　金：广西壮族自治区卫生厅科技计划资助课题(桂卫 9576)

摘　　要：目的　探讨急性大出血时及静脉输注6%羟乙基淀粉(6%HES)或单纯复方乳酸钠行 容量复苏后血清S100B蛋白(简称S100B)的变化,评价6%HES对减轻失血性休克时脑神经损害的 作用。方法　实验犬12只,随机分为6%HES治疗组(H组)和复方乳酸钠治疗组(L组),股动脉放 血复制成急性大出血动物模型。在放血造成失血性休克60min后分别静脉输注6%HES和复方乳 酸钠。于放血前(T0),放血完毕后60min(T1),液体治疗后30min(T2)、2h(T3)、4h(T4)抽取静脉 血测定血清S100B含量。结果　放血造成失血性休克后,两组S100B均显著升高(P<0.01);液体 治疗后2h和4h,S100B均比前一时点显著下降(P<0.01);液体治疗后,H组的S100B浓度显著低 于L组(P<0.01)。结论　急性大出血所致的失血性休克可导致血清S100B的急剧升高,提示急性 大出血及失血性休克可能导致中枢神经损害。有效的容量治疗可促使S100B逐步下降。6%HES 容量治疗对减少S100B的释放的效果优于复方乳酸钠。Objective To determine the change of serum S100B protein during acute massive haemorrhage and the effect of 6% hydroxyethyl starch(6% HES) solution on S100B in dogs.Methods Acute massive haemorrhage model was induced by blood withdrawal in dogs.Twelve dogs were divided randomly into 6% HES group(group H)and lactated Ringers solution(LR)(group L).At 60min after hemorrhage,the dogs were infused with 6% HES or LR.Blood samples were taken before bleeding(T 0),at 60min after bleeding(T 1),30min(T 2),2h(T 3)and 4h(T 4)after fluild resuscitation,and S100B was determined.Results After hemorrhage,the S100B of all dogs was increased significantly(P<0.01).The concentration of S100B in T 3 and T 4 was decreased more obviously than that of T 1 and T 2(P<0.01).S100B was lower in the groups resusicated with 6% HES than that in LR group.Conclusion The concentration of S100B increases significantly in dogs during acute massive haemorrhage,then gradually decreases after fluid resuscitation.But 6% HES infusion can greatly reduce the release of S100B,which is more than LR.

关 键 词：急性大出血 复苏 血清 S100B蛋白 羟乙基淀粉 脑功能 

分 类 号：R605[医药卫生—外科学]