动态检测新生儿病理性黄疸患儿血清α-GST的临床价值  

Clinical significance of monitoring serum α-glutathione stransferase of newborn with pathological jaundice

作　　者：曹银洁[1] 杨文东[2] 郑红英[1] 

机构地区：[1]胜利石油管理局中心医院检验科,山东东营257034 [2]利津县第二人民医院检验科,山东东营257447

出　　处：《检验医学》2005年第1期10-12,共3页Laboratory Medicine

摘　　要：　　目的　探讨动态检测新生儿病理性黄疸患儿血清α 谷胱甘肽 S 转移酶(α GST)对评估肝功能受损 情况的价值。方法　观察组为38例新生儿病理性黄疸患儿,对照组为34例生理性黄疸患儿及30名健康儿。 血清α GST的检测采用酶联免疫吸附试验(ELISA),丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)行 常规生化检测。结果　新生儿病理性黄疸患儿血清α GST在发病初期迅速升高(P<0.01),其峰值变化与同期 所测ALT和AST相比明显提早,经治疗后α GST迅速下降,快于治疗后ALT和AST值的变化。结论　动态检 测血清α GST能更敏感地反映肝功能受损情况,对新生儿病理性黄疸患儿的治疗有重要的临床价值。Objective To explore the significance of monitoring serum α-glutathione stransferases (α-GST) of newborns with pathological jaundice for estimating the damage of liver function. Methods 38 newborns with pathological jaundice, 34 newborns with physiological jaundice and 30 normal newborns were observed. The serum α-GST was determined by ELISA. Results The serum α-GST of newborn with pathological jaundice rised rapidly in early stage. The peak value appeared early than that of ALT and AST. After treatment the decrease of serum α-GST of newborn with pathological jaundice was more rapid than that of ALT and AST. Conclusions Monitoring serum α-GST can reflect sensitivly the damage of liver function and is helpful for the treatment of newborn with pathological jaundice.

关 键 词：α-GST 新生儿病理性黄疸 血清 患儿 临床价值 ALT AST 动态检测 峰值 

分 类 号：R722[医药卫生—儿科] R446[医药卫生—临床医学]