2-(1-苯基/取代苯基-3-甲基-5-氯-1H-4-吡唑基)-3-芳酰胺-4-噻唑啉酮的合成及生物活性  

Synthesis and Biological Activities of 2-(1-Aryl-3-methyl-5-chloro- 1H-pyrazol-4-yl)-3-(1-aroylamino)-4-thiazolidinones

作　　者：文丽荣[1] 李明[1] 景淑霞[1] 曹玮[1] 杨华铮[2] 

机构地区：[1]青岛科技大学化学与分子工程学院,青岛266042 [2]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《有机化学》2005年第2期197-200,共4页Chinese Journal of Organic Chemistry

基　　金：山东省自然科学基金(No.Y2003B01);国家自然科学基金(No.20172031)资助项目.

摘　　要：利用1-芳基-3-甲基-5-氯-1H-4-吡唑醛(2)分别与取代苯甲酰肼反应,进一步与巯基乙酸关环,合成了11个新的2-(1-芳基-3-甲基-5-氯-1H-4-吡唑基)-3-芳酰胺-4-噻唑啉酮类化合物3a～3k,并利用元素分析,IR,HNMR和X-ray晶1体衍射确定了其结构.初步生物活性表明:3e具有杀菌活性,3e和3k具有除草活性.The reactions of 1-aryl-3-methyl-5-chloro-1H-4-pyrazolylformaldehydes (2) with aroylhydrazines and followed by the addition of mercaptoacetic acid, eleven new compounds 2-(1-aryl-3-methyl-5chloro-1H-pyrazol-4-yl)-3-(1-aroylamino)-4-thiazolidinones 3asimilar to3k have been synthesized. Their structures were characterized by elemental analysis, IR and H-1 NMR spectra, and one of them 3d by X-ray diffraction study. The preliminary bioassay tests showed that compound 3e possessed moderate fungicidal activity and 3e and 3k only exhibited certain herbicidal activity.

关 键 词：甲基 芳基 吡唑 酰胺 合成 噻唑 取代苯基 酰肼 元素分析 NMR 

分 类 号：TQ453[化学工程—农药化工]