哒嗪酮衍生物的合成和生物活性研究  

Study on the Synthesis and Bioactivity of Pyridazinone Derivatives

作　　者：李洪森[1] 凌云[1] 郭钰来[1] 杨新玲[1] 陈馥衡[1] 

机构地区：[1]中国农业大学应用化学系,北京100094

出　　处：《有机化学》2005年第2期204-207,共4页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20272080)资助项目.

摘　　要：合成了16个含哒嗪酮环新化合物,所有化合物结构均通过HNMR,IR和元素分析确证.生物活性初步研究结1果表明,在200mg/kg浓度下,化合物7a,7b,7c和7d对二龄家蝇幼虫具有较好的杀虫活性,对三龄蝗蝻活性不明显.Sixteen compounds of pyridazinone derivatives were synthesized. Their structures were determined by H-1 NMR, IR spectra and elemental analysis. In the preliminary bioassay test, compounds 7a, 7b, 7c and 7d showed good activity against second-instar housefly larvae and lower activity for third-instar nymphs of locusts at concentration of 200 mg/kg.

关 键 词：哒嗪酮 合成 生物活性 杂环化合物 

分 类 号：TQ453[化学工程—农药化工]