21例多发伤患者血液炎症因子变化连续观察  

Continual Observation of PCT,TNF - α, IL - 6 on 21 Cases After Severe Multiple Trauma

作　　者：郭昌星[1] 林军[2] 单红卫[1] 杨兴易[1] 林兆奋[1] 赵良[1] 陈德昌[1] 胡卫青[1] 

机构地区：[1]上海长征医院急救科,200003 [2]厦门市中山医院急诊科

出　　处：《实用全科医学》2005年第2期101-102,共2页Applied Journal Of General Practice

摘　　要：目的连续观察21例严重多发伤患者血浆PCT、血清TNF-α、IL-6浓度变化。探讨其在危重病救治工作中的意义。方法21例严重多发伤患者分为多发伤组、多发伤合并多脏器功能不全未亡组,多发伤合并脏器功能不全死亡组,分别于伤后12h、24h、2d、3d、5d、10d和15d观察血浆PCT、血清TNF-α、IL-6浓度变化。结果 多发伤组患者PCT、TNF-α和IL-6早期有所升高,随病情好转即恢复正常;多发伤合并多脏器功能不全未亡组早期PCT浓度即升高,出现多脏器功能不全后又再次升高,以后随病情好转恢复正常,TNF-α和IL-6随病情加重而升高,病情好转即恢复正常;多发伤合并多脏器功能不全死亡组患者PCT、TNF-α和IL-6自伤后持续上升,无下降趋势,且浓度明显高于前两组患者(P<0.01)。结论PCT、TNF-α、IL-6在一定程度上能反应体内炎症反应程度,监测严重多发伤患者的PCT、TNF-α、IL-6水平有助于判断疾病的发展及预后。Objective To investigate the changing of PCT,TNF - α,IL - 6 in 21 cases who had severe multiple trauma so as to explore it's clinical signification. Methods 21 patients were divided into three groups and the concentration of PCT,TNF -α,IL- 6 were measured at the time 12 hour,24 huor,2rd,3th,5th, 10th, 15th day after trauma. Results The concentration of PCT,TNF- α, IL - 6 were obviously increased after trauma. In the later course of the disease, The concentration of PCT,TNF-α,IL- 6 in group 3(death group) were significantly higher than that in group 1 and group 2. Conclusions PCT,TNF - α,IL- 6 were involved in the pathological process of multiple trauma and might have the relevant with the severe multiple trauma.

关 键 词：多发伤 血液检查 炎症因子 降钙素原 TNF-α IL-6 炎症反应 

分 类 号：R59[医药卫生—内科学] R364.5[医药卫生—临床医学]