2,6-二甲酰基对甲苯酚的固相合成  

Solid Phase Synthesis of 2,6-Diformyl-4-methylphenol

作　　者：刘爱华[1] 岳凡[1] 封顺[1] 王吉德[1] 陈华梅[1] 杨红伟[1] 

机构地区：[1]新疆大学化学化工学院,新疆乌鲁木齐830046

出　　处：《合成化学》2005年第1期95-97,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以活性纳米γMnO2为氧化剂,在无溶剂状态下用2,6二甲羟基对甲苯酚为原料合成了2,6二甲酰基对甲苯酚,其结构经1HNMR,IR和元素分析确证。较适宜的反应条件为2,6二甲羟基对甲苯酚0.85g(5mmol),n(2,6二甲羟基对甲苯酚)∶n(活性γMnO2)=1∶2,间歇性研磨提供充分的自扩散时间(1h～2h),总研磨时间为5h～6h,收率26%。该法与液相合成法相比,反应时间缩短到1/8,产率提高了6%。Diformyl-4-methylphenol was prepared via solvent-free oxidation reation of 2,6-glycol-4-methylphenol using nanometer γ-MnO_2 as a oxidant at room temperature. Its structure was confirmed by 1H NMR, IR and elemental analysis. The apprpriate reaction conditions were as follows: 2,6-glycol-4-methylphenol was 5 mmol, n(2,6-glycol-4-methylphenol) ∶n(γ-MnO_2) was 1 ∶2, intermission time was 1 h^2 h, total grind time was 5 h^6 h. Compared with the liquidoid method, the reaction time of this method was much cut down with a improved yield, simpler operation, and lower pollution.

关 键 词：无溶剂合成 甲酰基 苯酚 纳米 MNO2 

分 类 号：O652.31[理学—分析化学]