五水四氯化锡催化合成氯乙酸正丁酯  

Synthesis of n-Butyl Chloroacetate Catalyzed by Stannic Chloride Pentahydrate

作　　者：文瑞明[1] 罗新湘[1] 游沛清[1] 俞善信[1] 

机构地区：[1]湖南城市学院化学与环境工程系,湖南益阳413049

出　　处：《合成化学》2005年第1期98-100,共3页Chinese Journal of Synthetic Chemistry

基　　金：湖南省科技计划资助项目(03JZY3034)

摘　　要：在五水四氯化锡存在下,由氯乙酸和正丁醇合成了氯乙酸正丁酯。实验结果表明,五水四氯化锡对酯化反应具有较高的催化活性。较适宜的反应条件为氯乙酸100mmol,n(氯乙酸)∶n(正丁醇)∶n(五水四氯化锡)=1∶1.5∶0.029,回流分水90min,酯化率91.3%。n-Butyl chloroacetate was synthesized from chloroacetic acid and n-butanol using stannic chloride pentahydrate as a catalyst. The experimental results indicated that stannic chloride pentahydrate exhibited high catalytic activity for the esterification reaction. The appropriate reaction conditions were as follows: chloroacetic acid was 100mmol, n(chloroacetic acid) ∶n(n-butanol)∶n^(SnCl_4· 5H_2O)=1.0 ∶1.5 ∶0.029, refluxing and water segrating for 90 min. The yield of the ester was 91.3% under the selected reaction conditions.

关 键 词：酯化 氯乙酸 正丁醇 氯乙酸正丁酯 五水四氯化锡 

分 类 号：O643.38[理学—物理化学]