酸性肽体外实验观察抗突变作用及其机理  

Antimutation of Acidic Peptide and Its Mechanism

作　　者：毛红丽[1] 王志超[1] 安玉会[1] 马红霞[1] 

机构地区：[1]郑州大学医学院生化教研室,河南郑州450052

出　　处：《河南肿瘤学杂志》2005年第1期17-19,共3页Henan Journal of Oncology

摘　　要：目的　体外实验观察酸性肽抗突变作用及其机理。方法　采用Ames实验TA98、TA10 0菌株 ,观察酸性肽对其回变菌落数的影响 ;采用不同的加药方式作用于TA98菌株 ,探讨酸性肽的抗突变机理。结果　酸性肽对这两种菌株的回变菌落数与阳性对照相比有显著性差异 ;A、B、D三种加药方式回变菌落数明显小于C组 ,有统计学意义 (P <0 0 5 )。结论　酸性肽有抗突变性 ,抗突变的机理是通过直接灭活致突变剂的作用 ,因而有保护细胞免受损伤的抗突变作用。Objective To study the antimutation of acidic peptide and its mechanism. Methods The antimutation of acidic peptide was detected by Ames test.Four different adding drug ways were used to discuss the mechanism of acidic peptide. Result 1)Comparing with positive group, acidic peptide groups could decrease the colonies in TA 98 and TA 100 strains.There was statistical difference among them. 2)In different adding drug way test,the way A,B,Dis better than the way C(P<0.05). Conclution acidic peptide had antimutation.The mechanism of antimutation of acidic peptide was inactivating mutagen directly.

关 键 词：酸性肽 抗突变作用 AMES实验 抗突变机理 

分 类 号：R971.2[医药卫生—药品]