壳聚糖辐射接枝MAA共聚物的制备及应用  

Preparation of Chitosan-MAA Radiation Graft Copolymers and its Application

作　　者：姚评佳[1] 王华瑜[2] 蒋林斌[2] 吕鸣群[3] 魏远安[1] 

机构地区：[1]广西亚热带生物资源保护利用重点实验室,广西南宁530005 [2]广西大学化学化工学院,广西南宁530004 [3]广西大学辐照中心,广西南宁530005

出　　处：《化工技术与开发》2005年第1期9-11,共3页Technology & Development of Chemical Industry

基　　金：广西区教育厅资助项目 (桂教科研 [2 0 0 3]2 2号 )

摘　　要：利用辐射源 6 0 Co辐照壳聚糖 (chitosan)与甲基丙烯酸 (MAA)接枝聚合反应 ,合成的共聚物可以作为药物非诺洛芬钙缓释制剂的载体。本文研究了壳聚糖与甲基丙烯酸不同配比、不同辐照剂量对接枝聚合产物性能的影响。用红外光谱仪 (FTIR)表征了接枝聚合产物 ,并以接枝聚合物为载体制备了药物非诺洛芬钙缓释片剂。通过测定药物片剂的非诺洛芬钙在人工肠液的缓释速率 。The grafting copolymerization of chitosan (Cts) and methacrylic acid (MAA) was carried out using radiation source ()^(60)Co.The synthesis product could be used as a carrier of fenoprofen calcium (FC). The influences of proportions of methacrylic acid (MAA), radiation dosages on performance of graft polymerization, were studied, and the grafted copolymer was identified by FT-IR. The examination of release rate of drugs in intestinal fluid showed that fenoprofen calcium in tablets was released slowly.

关 键 词：壳聚糖 甲基丙烯酸 接枝共聚 非诺洛芬钙 辐射源..Co 

分 类 号：TQ316.313[化学工程—高聚物工业]