化学促进剂与鼠角质层脂质相互作用的ATR-FTIR  

Interaction of four enhancers with the lipids of the mouse SC by ATR-FTIR

作　　者：张志慧[1] 周雪琴[1] 许晶[1] 姚康德[1] 刘东志[2] 张玉环[3] 

机构地区：[1]天津大学高分子材料研究所,天津300072 [2]天津大学化工学院,天津300072 [3]天津市长征医院,天津300021

出　　处：《化学研究与应用》2005年第1期64-65,共2页Chemical Research and Application

基　　金：国家重点基础研究发展规划项目(G199954305)

摘　　要：The mechanism of enhancers （methanol,chloroform,azone and thiozone） was studied in vitro in mouse stratum corneum （SC）.Attenuated total reflectance Fourier-transform infrared spectroscopy （ATR-FTIR） was applied to monitor the wavenumber shifts of CH2 stretching absorbance as well as the lipid content in the SC,which were used as criteria to explain the effect of the enhancers on mouse SC.The FTIR spectra record that treatment with these four enhancers would result in significant shifts toward higher wavenumber at vasCH2 and vsCH2 and the integration areas of vasCH2 and vsCH2 decrease when treatment of methanol and choloroform.It is concluded that these four enhancers could increase the gauche conformational isomer content of lipid CH2,made the lipid in the SC a more fluid state,thus the resistance of drug transdermal delivery was reduced.The mechanism of enhancers (methanol,chloroform,azone and thiozone) was studied in vitro in mouse stratum corneum (SC).Attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) was applied to monitor the wavenumber shifts of CH_2 stretching absorbance as well as the lipid content in the SC,which were used as criteria to explain the effect of the enhancers on mouse SC.The FTIR spectra record that treatment with these four enhancers would result in significant shifts toward higher wavenumber at v_(as)CH_2 and v_sCH_2 and the integration areas of v_(as)CH_2 and v_sCH_2 decrease when treatment of methanol and choloroform.It is concluded that these four enhancers could increase the gauche conformational isomer content of lipid CH_2,made the lipid in the SC a more fluid state,thus the resistance of drug transdermal delivery was reduced.

关 键 词：衰减反射付里叶红外光谱(ATR-FTIR) 鼠角质层 化学促进剂 脂质 

分 类 号：O629.73[理学—有机化学]