不同程度动脉硬化一氧化氮水平的变化及意义  

The variation of Nitric Oxide in patients with different degree arteriosclerosis and its significance

作　　者：李东霞[1] 潘志红[1] 张江蓉[1] 王一尘[1] 沈丽[1] 郑丽华[1] 

机构地区：[1]上海第二医科大学附属新华医院老年科,200092

出　　处：《实用心脑肺血管病杂志》2005年第1期6-8,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的　探讨一氧化氮(NO)水平在不同程度动脉粥样硬化(AS)中的变化及临床意义。　方法　通过脑阻抗血流图的硝酸甘油药物试验检测进行AS分组,测定不同AS组及正常对照组NO含量,进行组间比较。　结果　各组间NO含量及脑阻抗血流图检测指标比较结果均差异显著(P<005),并有统计学意义。　结论　NO在AS发病中起重要作用,并与AS程度有定量关系。Objective To evaluate the variation of Nitric Oxide(NO) in the different degree arteriosclerosis(AS) and its clinical significance. Methods Patients received cerebral impedance chart nitroglycerin test to be classified into 3 groups:mild,moderate and severe AS.The levels of plasma NO were tested in these groups and the normal control.The results were compared with each other. Results The values of each group were compared respectively.There were significant difference of NO among them(P<0.05). Conclusion The results showed that NO had played an important role in the initiation and progress of AS and there was a quantitative relation between the degree of AS and the concentration of NO.

关 键 词：阻抗血流图 动脉硬化 NO含量 一氧化氮 动脉粥样硬化(AS) 对照组 正常 药物试验 发病 硝酸甘油 

分 类 号：R541[医药卫生—心血管疾病] R962[医药卫生—内科学]