1-(2,6,6-三甲基-1-环己烯基-)-3-甲基-2-丁烯-4-醛合成新工艺  

A New Synthesis Technology of 1-(2,6,6-Trimethyl-1-cyclohexenyl)-3-methyl-2-buten-4-al

作　　者：闫海英[1] 杨泽慧[1] 杨绿[1] 陈新志[1] 

机构地区：[1]浙江大学材料与化学工程学院,杭州310027

出　　处：《应用化学》2005年第2期213-215,共3页Chinese Journal of Applied Chemistry

摘　　要：The present paper covers a new process for the synthesis of 1-（2,6,6-trimethyl-1-cyclohexenyl）-3-methyl-2-buten-4-al with dimethyl sulfide, bromomethane and β-ionone as primary materials in four steps, via the carbine reaction of dimethyl sulfide and bromomethane, the cyclization of trimethylsulfonium bromide and β-ionone, the opening of epoxy compound and isomerization of C14-aldehyde. The overall yield is 77%. The structure of the titled product was characterized by GC/MS, IR and 1H NMR. The process has many advantages such as facile low-cost materials, high conversion, short reaction time, mild reaction ondition, and less by-products. Furthermore, the part materials can be recycled, the cost and pollution are reduced, so it is feasible for industry production.The present paper covers a new process for the synthesis of 1-(2,6,6-trimethyl-1-cyclohexenyl)-3-methyl-2-buten-4-al with dimethyl sulfide, bromomethane and β-ionone as primary materials in four steps, via the carbine reaction of dimethyl sulfide and bromomethane, the cyclization of trimethylsulfonium bromide and β-ionone, the opening of epoxy compound and isomerization of C_14-aldehyde. The overall yield is 77%. The structure of the titled product was characterized by GC/MS, IR and 1H NMR. The process has many advantages such as facile low-cost materials, high conversion, short reaction time, mild reaction ondition, and less by-products. Furthermore, the part materials can be recycled, the cost and pollution are reduced, so it is feasible for industry production.

关 键 词：(三甲基环己烯基)甲基丁烯醛 卡宾反应 Β-紫罗兰酮 三甲基溴化硫 

分 类 号：O623.5[理学—有机化学]