维生素E与维生素C联合治疗对糖耐量受损患者糖代谢的影响  

Effects of vitamin C and vitamin E combination therapy on glucose metabolism in IGT patients

作　　者：毛晓明[1] 刘志民[1] 石勇栓[1] 蒋克春[2] 王爱萍[2] 饶亚平[2] 

机构地区：[1]上海长征医院内分泌科 [2]解放军第四五四医院内分泌科

出　　处：《中华糖尿病杂志（1006-6187）》2004年第6期413-416,共4页

摘　　要：目的　观察维生素C与维生素E联合治疗对糖耐量受损 (IGT)患者糖代谢的影响。　方法　以口服葡萄糖耐量试验 (OGTT)筛查IGT患者 15 9例 ,随机分成治疗组和对照组 ,治疗组予口服维生素C 5 0 0mg/d及维生素E 2 0 0mg/d ,6个月 ;对照组不进行任何治疗。分别于治疗前后检测血糖 (PG)及胰岛素 (Ins) ,用稳态模型评价胰岛素抵抗指数 (HOMA IR)及胰岛细胞分泌功能指数(HOMA β)。 　结果　治疗组FPG、Ins及HOMA IR较试验前及对照组均明显下降 ,HOMA β无明显变化。对照组试验前后各项指标无明显变化。试验结束时 ,对照组有 3例转为糖尿病 (DM ) ,占3 8% ,治疗组无DM发生。经 χ2 检验两组DM的发生率差异无显著意义 (χ2 =3 8,P >0 0 5 )。　结论　维生素C与维生素E联合应用可以改善IGT患者的糖代谢 ,减轻其IR。Objective To observe the effects of vitamin(Vit) C and vit E combination therapy on glucose metabolism in impaired glucose tolerance (IGT) patients Methods 159 patients with IGT [fasting plasma glucose (FPG)<7 0 mmol/L and 2 h plasma glucose (PG2 h)≥7 8 mmol/L<11 1 mmol/L] were diagnosed by standard oral glucose tolerance test (OGTT) The patients were randomized into treatment(T, n =81) and control(C, n =78) groups The T group were treated with vit C (500 mg/d) and vit E (200 mg/d) for 6 months The C group had not any treatment The FPG and insulin were measured The insulin resistance (HOMA IR) and β cell function (HOMA β) were evaluated by the homeostasis model Results FPG, insulin and HOMA IR were significantly reduced in T group vs C group of IGT patients Significant difference was not noted in HOMA β between the T and C groups Three new diabetic patients appeared in C group (3 8%) and none of diabetes in T group at the end of the study, P >0 05 Conclusions Conclusions vit C vit E combination therapy can improve glucose metabolism and alleviate insulin resistance in the IGT patients

关 键 词：对照组 患者 治疗组 维生素E 维生素C 糖耐量受损 糖代谢 IGT 联合治疗 DM 

分 类 号：R587.1[医药卫生—内分泌]