益母草中生物碱成分对大鼠的利尿作用研究  

The Diuretic Effect of Alkaloids from Yimu Cao (Herba Leonuri) on Rat

作　　者：晁志[1] 马丽玲 周秀佳[3] 

机构地区：[1]中国人民解放军第一军医大学,广东广州510515 [2]广州卫生学校,广东广州510515 [3]上海中医药大学中药学院,上海200032

出　　处：《时珍国医国药》2005年第1期11-12,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的 :研究益母草中生物碱成分对大鼠的利尿作用。方法 :三组动物分别用生理盐水、益母草碱溶液、水苏碱溶液2 .5 ml/ 10 0 g灌胃 ,测定记录排出尿量 ,测定尿液中 K+ ,Na+ ,Cl-含量。结果 :水苏碱能显著增加大鼠尿量 ,益母草碱也有一定效果 ,其作用均在 2 h内达到高峰。相比较而言 ,水苏碱作用更加迅速 ,而益母草碱作用较为和缓。尿液中的离子分析表明 ,两种生物碱成分增加 Na+的排出量 ,而使 K+的排出量减少 ,Cl-也有所增加。结论 :益母草可作为一种作用和缓的保钾利尿药使用。Objective:To study the diuretic effect of alkaloids from Yimu Cao (Herba Leonuri, aerial part of Leonurus heterophyllas, Lamiaceae) on rat.Methods:SD rats were divided into 3 groups and given NS, stachydrine (1.0 mg/ml) and leonurine (1.0 mg/ml) p.o. at 2.5 ml/100 g respectively. Urine was collected, its amount and K+,Na+,Cl- in it were determined.Results:That stachydrine could increase the excretion of urine significantly, and leonurine was also diuretic to some extent; the effect of both alkaloids reached peak in 2 hours. In comparison with each other, stachydrine showed much faster effect, while leonurine was a little moderate. Analysis of ions in urine indicated that both of the alkaloids could increase the secretion of Na+, but decrease that of K+; the amount of Cl- slightly increased.Conclusion:Yimu Cao can be used as a moderate diuretic keeping potassium.

关 键 词：益母草 益母草碱 水苏碱 利尿 ' 

分 类 号：R285.5[医药卫生—中药学]