中药四性的生物热动力学研究——左金丸与反左金寒热药性的微量热学比较  

Biothermokinetic studies on four properties of traditional Chinese medicine: comparison of properties of Zuojinwan and Fanzuojin by microcalorimetry

作　　者：周韶华[1] 肖小河[1] 赵艳玲[1] 代春美[1] 朱军成[2] 刘义[2] 

机构地区：[1]解放军302医院药学部 [2]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《中国中药杂志》2004年第12期1183-1186,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目 (C0 3 0 3 0 2 0 8;2 0 0 0 I Q 1)

摘　　要：目的 :从生物物理和生物化学的角度 ,探讨中药药性的客观真实性。方法 :利用微量热法 ,测定了大肠杆菌在左金丸、反左金水煮液作用下的生长热谱曲线 ,得到了相应的生物热动力学参数 ,结合本草文献报道 ,综合分析了左金丸与反左金的药性差异。结果 :左金丸、反左金水煮液均能不同程度地抑制细菌的生长 ,温热药方反左金使细菌指数生长期的生长速率常数显著减小 ,生长代谢过程中热量释放显著增加。寒凉药方左金丸则使细菌指数生长期的生长速率常数减小 ,生长代谢过程中热量释放有所增加 ,两者存在较稳定的差异。结论 :微量热法可作为刻划中药药性的有效的新方法。Objective: To probe into the objectivity and authenticity of four properties(cold, heat, warm and cool) of traditional Chinese medicine(TCM) from biophysics and biochemistry Method: Microcalorimetry was used to obtain the metabolic growth power time curves of Escherichia coli and biothermokinetic parameters Combined with the records of ancient herbal literatures, the difference of properties of Zuojinwan and Fanzuojin were synthetically evaluated Result:Both the decoction of Zuojinwan and Fanzuojin can restrain the growth and metabolism of the bacteria in different levels. Drugs with Warm Property can decrease the multiplication rate constants and increase heat output remarkably, while drugs with cool property can decrease the multiplication rate constants and increase heat output a little There was a stable difference between them Conclusion: Microcalorimetry is a new and useful means for the study of the properties of TCM

关 键 词：左金丸 中药药性 细菌指数 寒热 药方 生物热 本草 生长期 生长代谢 生长速率 

分 类 号：R285.1[医药卫生—中药学]