益气通络丹对冠心病、高血压病患者血液氧自由基、NO及纤溶活性的影响  

Effects of "Yi Qi Tong Luo Dan" on Plasma Free Radicals,Nitric Oxideand Fibrinolytic activities in Ischemic Heart Diseases and Hypertension Patients

作　　者：沈剑刚[1] 郭志刚[1] 佟丽[1] 陈育尧[1] 姜翼[1] 许文学[1] 

机构地区：[1]第一军医大学中医系

出　　处：《中药药理与临床》1996年第3期42-44,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金

摘　　要：对冠心病、高血压病患者益气通络丹治疗前后血浆脂质过氧化物（ＬＰＯ）、超氧化物歧化酶（ＳＯＤ）、一氧化氮（ＮＯ）及组织型纤溶酶原激活物（ｔ－ＰＡ）及其抑制物（ＰＡＩ）水平观察显示：冠心病、高血压病患者血浆ＬＰＯ水平显著高于正常对照组，而ＮＯ、ＳＯＤ、ｔ－ＰＡ水平均显著低于正常对照组。益气通络丹治疗以后血浆ＬＰＯ、ＰＡＩ水平显著降低，ＮＯ、ＳＯＤ、ｔ－ＰＡ水平显著升高。提示益气通络丹治疗冠心病、高血压病的作用机制与其抑制脂质过氧化、增强抗氧化酶活力、调节纤溶活性及促进ＮＯ释放有关。t Was investigated that the chanscy of lipid peroaldes(LPO),superoxide dismutase(SOD), nitric oxide(NO) andtissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI) in plasma of the ischemic heart dis-eases and hpprtension patients. In the patients group,the levels of LPO and PAI were significantly higher than that ofthe control group,while the levels of NO,SOD and t-PA were significantly lower than that of the control group. Aftertaking'Yi Qi Tong Luo Dan' (a prescription of Chinese medicine) for 15 days,the levels of LPO and PAl were de-creased and the levels of NO,SOD and t-PA were increased significantly in the ischemic heart disease and hypertensionpatients. The results suggested the mechanism of 'Yi Qi Tong Luo Dan' against ischemic heart disease and hypertensionare correlated with the properties of inhibiting lipid Perokidation,improvins the activities of antiokidant enzymes andadjusting fibrinolytiC activitics.

关 键 词：益气通络丹 冠心病 高血压病 患者 治疗 T-PA LPO 液氧 增强 降低 

分 类 号：R259.414[医药卫生—中西医结合] R544.1[医药卫生—中医内科学]