知母对甲亢模型β受体－cAMP系统的调节作用  

The Effects of Zhimu (Rhizoma Anemarrhenae) on βAR cAMP System in Hyperthyroid animal models

作　　者：刘洁[1] 翁世艾[1] 曹永舒[1] 夏宗勤[2] 易宁育[2] 

机构地区：[1]河南医科大学药理教研室 [2]上海第二医科大学细胞调控研究室

出　　处：《中药药理与临床》1996年第4期16-18,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：以放射免疫分析法和放射配基结合分析法观察了知母对甲亢模型β肾上腺素受体－ｃＡＭＰ系统的调节作用，结果表明，甲亢模型β受体－ｃＡＭＰ系统对β受体激动剂异丙肾上腺素的反应性显著增强，肾脏β受体最大结合容量也显著增加，知母能使两者降至近正常水平，但对β受体的亲和力无影响。此外，知母尚可降低甲亢模型的耗氧率，但不影响其血清Ｔ３和Ｔ４的水平黄皮叶氯仿提取物对小鼠因注射ＣＣｌ４、扑热息痛、硫代乙酰胺所致的肝损伤均有明显保护作用，使ＳＧＰＴ降低，肝脏病理损害减轻，并能增强肝脏的解毒功能。从黄皮叶氯仿提取物中分离出的黄皮酰胺等９种单体除去甲基原黄皮酰胺外均有降ＳＧＴＰ作用。The pathological models of “Yin deficiency” syndrome were produced by injecting triiodothyronine into mice or rats.The peak value of plasma cAMP contents after a single subcutaneous dose of isoproterenol was measured with RIA as an index of the response of βAR cAMP system.The maximum binding capacity (R T) and affinity of kidney βAR were estimated by 3H DHA binding assay.It was found that both the elevated responsiveness of βAR cAMP system and the increased R T value of βAR induced by triiodothyronine were reduced to nomal level by Zhimu-one of the Yin tonics.The results,together with the similar results of other Yin tonics such as Radix Rehmannia and Plastrum Testudinis reported before,strongly suggest that the regulatory action on βAR cAMP system is closely related to the theropeutic effects of some Yin tonics.

关 键 词：甲亢 肾上腺素受体 知母 调节作用 AMP 放射配基 正常 增强 降低 水平 

分 类 号：R581.1[医药卫生—内分泌] R282[医药卫生—内科学]