银杏外种皮多糖对小鼠肿瘤的抑制作用  

The Suppressive Effects of Ginkgo Biloba Enocarp Polysaccharides(GBEP) on Tumor in Mice

作　　者：许爱华[1] 陈华圣[1] 项晓仁[1] 顾维戎[1] 张洪泉[1] 

机构地区：[1]扬州大学医学院,225001

出　　处：《中药药理与临床》1996年第5期24-26,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：江苏省教委自然科学基金

摘　　要：银杏外种皮多糖(GBEP)体外可抑制S_(180)细胞的增殖。灌胃给药,能延长EAC小鼠的生存期,抑制小鼠S_(180)移植性实体瘤的生长;超微结构观察,该实体瘤细胞膜结构被破坏,部分细胞器裂解成碎片。GBEP对环磷酰胺所致小鼠骨髓有核细胞数的抑制还具有保护作用。In vitro GBEP caused a decrease of the proliferation of S_(180) cells. The oral administration of GBEP showed that it could prolong the life of EAC mice and inhibit the growth of the solid tumor S_(180) in mice. Ultrastructural examination showed that the membrance structure of S_(180) cells of the group with GBEP were destroyed and some cell-organ split became pieces. GBEP also could antagonize the suppressive effect of cyclophosphamide on the bone marrow cells in mice.

关 键 词：银杏外种皮多糖 小鼠肿瘤 实体瘤 抑制作用 瘤细胞 S180细胞 体外 裂解 EA 膜结构 

分 类 号：R285.5[医药卫生—中药学] R730[医药卫生—中医学]