复方贞杞口服液药理作用研究  

Pharmacological Property Compound Zhenqi Oral Liquid

作　　者：张玉芳[1] 吴玉波[1] 张永恒[1] 彭世云[2] 

机构地区：[1]哈尔滨医科大学肿瘤药研究所,哈尔滨150040 [2]哈尔滨医科大学附属三院检验科

出　　处：《中国临床药理学与治疗学》1996年第2期115-117,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 观察复方贞杞口服液对化疗药物丝裂霉素(MMC)、环磷酰胺(CTX)抗肿瘤活性及某些衰老指标的影响.方法采用动物移植瘤S_180、H_22模型,对复方杞口服液与MMC、CTX合用的抗肿瘤活性及免疫功能进行检测.采用18月龄老年和1月龄青年鼠模型,用MDA-TBA比色法测MDA含量,用光还原NBT法测SOD活性,用分光光度法测MAO—B活性.结果复方贞杞口服液明显增加MMC、CTX抗肿瘤活性,对其所引起免疫抑制性有明显保护作用;并能明显降低小鼠脏器组织中MDA含量,抑制MAO-B活性,增强SOD活性.结论 复方贞杞口服液能增强机体的免疫功能,对老化代谢产物及相关酶活性的影响,可能是对化疗药物增效解毒及抗衰老作用的机制.Aim The influence of the compound Zhenqi oral liquid both on the antineoplastic activity ofchemotherapy drugs MMC and CTX and on certain senility indexes was to be observed.Method Antineoplastic activity of the compoud used alone and in combination with MMCand CTX and its immunlogical function were observed in both senile(18 months )and young (1month) mouse transplanted tumor models. The MDA content was detected by MDA - TSAcolorimetry, SOD activity by photoreduced NBT method, and MAO - B activity by spec-trophotometry. Result It was revealed that the compound Zhenqi liquid obviously increasedthe antineoplastic activity of MMC and CTX, decreased the MDA concentration in tissues ofmouse internal organs, inhibited the MAO - B activity, enhanced SOD activity and preventedthe immusuppress induced by MMC and CTX. Conclusion The compoud Zhenqi oral liquid hasthe properties of synergia, detoxification and antisenility which result from its enhance ofimmunological function and regulation of metabolism and related enzymatic activity.

关 键 词：复方贞杞口服液 免疫功能 抗肿瘤 抗衰老 

分 类 号：R285.5[医药卫生—中药学]