实验小鼠痘病毒感染检测分析  

Analysis of Ectromelia(Mousepox) Virus Infection in Laboratory Mice

作　　者：应贤平[1] 钱琴[1] 屈霞琴[1] 姜文琴[1] 潘振业[1] 

机构地区：[1]卫生部上海生物制品研究所,上海200051

出　　处：《中国实验动物学杂志》2000年第2期69-73,共5页Chinese Journal of Laboratory Animal Science

摘　　要：小鼠痘病毒急性感染可导致实验小鼠脱脚病 (鼠痘 )发作 ,临床症状明显 ,发病动物短期内大量死亡。近 10年某地区鼠痘发生次数依次为昆明小鼠 (7次 )、NIH小鼠 (3次 )、ICR小鼠 (2次 )和BABL c小鼠 (1次 )。无明显临床症状慢性持续性感染 (隐性感染 ) ,是病毒传播或转化成急性感染主要原因 ,用免疫荧光技术 (IFA)可检测到病毒抗体 ,鸡胚病毒培养意义不大。流行病学调查证实IFA抗体阳性小鼠群体脱脚病发病率显著高于IFA抗体阴性小鼠群体 (P <0 0 0 1)。There were found Mousepox Virus (MPV) acute or chronic infection in laboratory mice.Seven,three,two and one acute infection of MPV occurred in Kunming,NIH,ICR and BALB/c mice respectively in near 10 years.MPV chronic persistent infection was demonstrated by immunofluorescence assay(IFA). Both retrospective and prospective epidemiological surveys confirmed that IFA positive was related to outbreak of Ectromelia. IFA should be applied for monitoring chronic persistent infection of MPV in mice.

关 键 词：实验小鼠 急性感染 抗体阳性 IFA NIH小鼠 发作 慢性 鼠痘病毒 毒感染 临床症状 

分 类 号：Q954.4[生物学—动物学] R512[医药卫生—内科学]