救心复脉注射液致突作用研究  

Studies on Mutagenicity of Jiuxin Fumai Injection

作　　者：汤百争[1] 李频[1] 严国爱[1] 周智君[1] 方云祥[1] 

机构地区：[1]湖南医科大学实验动物学部,长沙410078

出　　处：《中国实验动物学杂志》2000年第2期74-77,共4页Chinese Journal of Laboratory Animal Science

摘　　要：本文用Ames实验、体外染色体畸变实验、微核试验对救心复脉注射液进行了致突变性研究。结果显示 ,救心复脉 (JiuxinFumai,JXFM)注射液对TA97、TA98、TA10 0 、TA10 2 菌株无致突变性 ;体外细胞染色体畸变实验未引起CHO细胞染色体畸变 ,实验未引起CHO细胞染色体畸变率的升高 ;2 .0g kg、4 0g kg、8 0g kg的救心复脉注射液对小鼠骨髓多染红细胞无诱发微核增加作用。实验结果表明 ,救心复脉注射液无致突变作用。In this paper,the effect of mutagenicity of the Jiuxin Fumai Injection was investigated.The results showed that Jiuxin Fumai Injection did not induce positive mutation of strains TA 97 , TA 98 ,TA 100 and TA 102 in the Ames test.The rates of CHO chromosome aberration of Jiuxin Fumai Injection were negative range(<5%).The results of micronucleus assay of polychromatic erythrocytes in mice of Jiuxin Fumai Injection at 3 doses of 2.0 g/kg, 4.0 g/kg, 8.0 g/kg would not be to induce increase of its micronuclei.It was proved that Jiuxin Fumai Injection had no any mutagenicity in this experiment.

关 键 词：注射液 体外 作用研究 染色体畸变率 致突变性 CHO细胞 TA 菌株 微核 实验结果 

分 类 号：Q786[生物学—分子生物学] R927[医药卫生—药学]