裸鼠肾包膜下人癌模型在抗癌药物个体化疗中的应用  

An Animal Model of Human Tumor in Subrenal Capsule of Nude Mice for Clinical Individual Chemotherapy

作　　者：黄文革[1] 郭芬芬[1] 陈凤英[1] 陈颖青[1] 黄冰[1] 陈系古[1] 

机构地区：[1]中山医科大学实验动物中心,广州510089

出　　处：《中国实验动物学杂志》2000年第3期134-138,共5页Chinese Journal of Laboratory Animal Science

基　　金：本研究课题获得广东省卫生研究基金资助!(96-11-202005)

摘　　要：目的 通过临床病人肿瘤组织抗肿瘤药物敏感试验，为临床个体化治疗提供重要依据。方法 应用裸鼠肾包膜下人癌模型抗肿瘤药物敏感试验测试12种临床常用的抗肿瘤药物，确定出每例肿瘤最敏感药物，并向临床医生推荐使用。结果 共测试了临床肿瘤标本35例，包括肺腺癌、口腔鳞癌、结肠腺癌、乳腺癌和脑星形细胞瘤等。各个病例的最敏感药物不尽相同。结论 不同类型肿瘤以及相同类型肿瘤不同个体对肿瘤药物敏感度不同。该试验可能提高临床个体化疗效果。Objective To provide important data for clinical individual chemotherapy by a sensitive test of antitumor drugs in an animal model. Methods Antitumor sensitive test of 12 drugs was used in an tumor model of subrenal capsule in nude mice.Results 35 cases were totaled covering adenocarcinoma of lung, squamous carcinoma of oral cavity, adenocarcinoma of colon, mammary carcinoma and glioma. The most optimal sensitive drugs were not always the same in different cases. Conclusion The sensitivity of antitumor drugs is varied in different kinds of tumor as well as in different individual of the same kind of tumor. The results might improve the effect of tumor individual chemotherapy in clinic.

关 键 词：临床 裸鼠 抗肿瘤药物 敏感试验 个体化 抗癌药物 化疗 推荐使用 应用 病例 

分 类 号：Q959.1[生物学—动物学] R979.1[医药卫生—药品]