小剂量依那普利对大鼠急性心肌梗死左室重构和功能的影响  

The beneficial effect of infra-low dose of enalapril on the prevention of left ventricular remodeling after acute myocardial infarction in the rat

作　　者：张沛[1] 杨跃进[1] 宋来凤[1] 阮英茆[1] 周燕文[1] 田毅[1] 陈纪林[1] 陈在嘉[1] 徐义枢[1] 

机构地区：[1]中国医学科学院

出　　处：《中华老年心脑血管病杂志》2000年第6期408-411,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家教委回国启动基金

摘　　要：目的　评价小剂量依那普利 (ILDEn)对大鼠急性心肌梗死 (AMI)左室重构 (LVRM)和功能的影响。方法　AMI雌性SD大鼠 49只 ,随机分成AMI组 (2 4只 )和ILDEn治疗 (0 .1mg·kg-1·d-1)组 (2 5只 ) ;另有正常组 (10只 )和假手术组(13只 )大鼠作对照。直接灌胃法给药 4周后均行血流动力学测定、心脏标本固定和病理分析。去除死亡大鼠及舒张不良和梗死面积 <35 %或 >5 5 %的心脏标本后 ,最终分组为 :(1)AMI组 13只 ;(2 )ILDEn组 12只 ;(3)假手术组 8只 ;(4 )正常组 9只。结果　假手术与正常组各项指标比较 ,差异均无显著性意义 ;AMI和ILDEn组梗死面积比较 ,也无显著差异 (4 6 .7% ,46 .2 % )。与假手术组相比 ,AMI组左室舒张末压 (LVEDP)、容积 (LVV)、实际重量 (LVAW )和相对重量(LVRW)均显著增加 ;而左室内压最大上升和下降速率 (±dp/dt)及其左室收缩压 (LVSP)的校正值 (±dp/dt/LVSP)均显著降低。与AMI组相比 ,ILDEn组LVEDP显著降低 (12 .7mmHg,19.7mmHg) ,LVV显著减小 (0 .6 8ml,0 .80ml) ,LVAW和LVRW均显著减轻 (LVAW :6 6 5mg ,76 1mg ;LVRW :2 .45mg/g ,2 .79mg/g) ;而±dp/dt及其校正值均无显著变化。结论　小剂量依那普利能改善AMI大鼠血流动力学 ,有效防治左室重构 ,但对左室功能无影响。Objective To assess the effect of infra low dose of enalapril (ILDEn) on prevention of left ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in the rat.Methods Fourty nine female SD rats surviving AMI,which was achieved by ligating coronary artery,were randomized to AMI controls (n=24) or ILDEn (0.1 mg·kg -1 ·d -1 ) treatment group (n=25).Meanwhile,sham operated (n=13) and normal rats (n=10) were randomly selected to serve as non infarction controls.ILDEn was administered by direct gastric gavage.Four weeks after the therapy,hemodynamic measurement was performed in each group.Subsequently,the hearts of rats were fixed and pathological analysis was performed on them.Excluding the dead rats during the treatment and the hearts improperly fixed or with the MI areas <35% or >55%,complete experimental data were obtained in 42 rats,which were comprised of (1) AMI controls (n=13),(2) ILDEn group (n=12),(3) sham operated(n=8) and (4) normal controls (n=9).Results There were no significant differences in all indices between sham operated and normal rats.There was also no significant difference in MI size between AMI and ILDEn groups (46.7% vs 46.2%).Compared with sham operated rats,the left ventricular (LV ) end diastolic pressure (LVEDP),volume (LVV),absolute and relative weight (LVAW and LVRW) in AMI controls were significantly increased (all P<0.001),while the maximum rising and dropping rates of LV pressure(±dp/dt) and their values corrected by LV systolic pressure (±dp/dt/LVSP) in AMI group were significantly reduced (P<0.01-0.001).In contrast,compared with AMI controls,LVEDP,LVV,LVAW and LVRW were significantly reduced in ILDEn group(LVEDP: 12.7±5.6 vs 19.7±5.7 mmHg,P<0.01; LVV: 0.68±0.11 vs 0.80±0.11 ml,P<0.01; LVAW: 664.9±71.0 vs 761.2±149.7 mg,P<0.05; LVRW: 2.45±0.29 vs 2.79±0.43 mg/g,P<0.05);but±dp/dt and their corrected values were not significantly changed.Conclusion Infra

关 键 词：心肌粳塞 左室重构 依那普利 大鼠 

分 类 号：R542.22[医药卫生—心血管疾病]