IRM-2近交系小鼠对电离辐射抗性的研究  

Study on the Resistance of IRM-2 Mouse to Ionizing Radiation

作　　者：周继文[1] 吴红英[1] 王月英[1] 赵忠萍[1] 岳井银[1] 吴美羔[1] 刘鹏[1] 张荷清[1] 穆传杰[1] 

机构地区：[1]中国医学科学院中国协和医科大学放射医学研究所,天津300192

出　　处：《中国实验动物学报》2001年第2期73-77,共5页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家"九五"重点项目! (96 A2 3 0 6 0 4 )

摘　　要：目的　观察IRM 2小鼠对电离辐射的耐受性。方法　分析测定了IRM 2小鼠对137Csγ射线的LD50 及经 4 0Gy137Csγ射线照射后不同时间外周血白细胞、骨髓有核细胞总数、骨髓细胞DNA含量和脾结节的变化 ,并与亲代小鼠ICR和 61 5进行了比较。结果　用不同剂量的137Csγ射线照射后 ,IRM 2小鼠对γ射线的LD50 比ICR和 61 5小鼠分别高 1 73～1 57Gy和 1 44Gy ;外周血白细胞数和骨髓有核细胞总数、骨髓细胞DNA含量下降的幅度小且恢复得快 ;CFU S的增加也较ICR和 61 5小鼠明显。结论　IRMObjective\ The aim of this study is to determine the resistance of the IRM-2 inbred strain mouse to ionizing radiation.Methods\ Examinations for the changes of nucleated cell count in bone marrow,DNA content of bone marrow cells,WBC in peripheral blood and CFU-S were performed in IRM-2 mouse following irradiated with 4.0 Gy of 137Cs γ-rays.Results\ A declining degree of WBC,the nucleated cell count and DNA content in IRM-2 mouse after irradiating was lower but their recovery was quicker than in both ICR and 615 mouse.CFU-S in IRM-2 was 2 times higher than in both ICR and 615. LD 50 of IRM-2 mouse to γ-rays were 7.17(♂)-7.50(♀)Gy,that is, 1.73-1.57 Gy and 1.44 Gy higher than those of ICR and 615(P<0.01),respectively.Conclusion\ IRM-2 mouse possessed higher resistance to ionizing radiation than other inbred and outbred strain mouse.\;

关 键 词：小鼠 ICR 外周血白细胞 骨髓有核细胞 骨髓细胞 Γ射线照射 DNA含量 纯系 品系 抗性 

分 类 号：Q78[生物学—分子生物学] R285.5[医药卫生—中药学]