^(99m)Tc-MIBI心肌断层定量显像与冠状动脉造影对体外反搏促新生血管形成作用的实验研究  

The Experimental Research of External Counterpulsation Promotes Coronary Angiogenesis by Myocardial SPECT Quantitation and Coronary Artery Angiography

作　　者：梁宏[1] 伍贵富[2] 李伟明[1] 

机构地区：[1]中山医科大学第一附属医院核医学科,广州510080 [2]中山医科大学第一附属医院心血管医学部,广州510080

出　　处：《中国医学影像学杂志》2002年第1期43-45,共3页Chinese Journal of Medical Imaging

基　　金：广东省自然科学基金资助 (950 338)

摘　　要：目的 :应用99mTc MIBI心肌血流断层定量显像及冠状动脉造影研究增强型体外反搏 (EECP)对促冠脉侧支循环形成及改善心肌血供的价值。材料和方法 :12只闭胸式心肌梗塞模型犬均分为对照组和EECP治疗组 ,99mTc MIBI心肌断层定量显像在术后 4～ 6天及第 6周实验结束时进行 ,计算心肌缺损分数 (DF)及心肌挽救分数 (MSF =首次显像DF—后次显像DF)。结果 :EECP组心肌显像有 83 .3 % (5 /6)的实验犬治疗后心肌缺血改善 ,而对照组仅 1只 (16.6% )好转 ,且MSF值呈负值。冠脉造影与免疫组化染色分析表明EECP组冠脉侧枝开放数量及阳性染色区域面积也明显多于对照组。结论Purpose: To study the value of external counterpulsation on promoting coronary angiogenesis and improving myocardial blood perfusion by myocardial SPECT quantitation and coronary artery angiography. Materials and Methods: 12 canines with coronary occlusion by closed-chest model were divided into contrast group and enhanced external counterpulsation (EECP) group. All canines were performed 99m Tc MIBI myocardial SPECT 4-6 days after coronary occlusion and at the end of study. The myocardium defect fraction (DF) and saved fractions (MSF=first DF-post DF)were calculated. Results: Myocardial blood increased in 83.3%(5/6)experimental canines with EECP therapy,and in only 16.6%(1/6) of contraol group with negative MSF. The results also showed that the amount of coronay collaterals and positive stained area was significantly higher in EECP group than in contrast group by coronary artery angiography and immunohistchemical analysis. Conclusion: Results indicate EECP could increase coronay collaterals and decrease the infarct areas effectively.

关 键 词：^99MTC-MIBI 对照组 体外反搏 冠状动脉造影 心肌梗塞 新生血管形成 治疗 挽救 增强型 提示 

分 类 号：R542[医药卫生—心血管疾病] R541.4[医药卫生—内科学]