SLE患者T淋巴细胞IL—2R和血清sIL—2R水平变化的研究  

Study on the Changes of IL—2R Molecules on the T lymphocytes and Concentration of Serum sIL-2R in patients with SLE

作　　者：杨惠斌[1] 殷志伟[1] 谢平[1] 罗建君 胡玉敏[1] 茅子均[1] 

机构地区：[1]苏州医学院病理生理学教研室

出　　处：《苏州医学院学报》1993年第4期266-269,共4页Acta Academiae Medicinae Suzhou

基　　金：江苏省科学技术委员会资助课题

摘　　要：采用受体免疫放射分析法和ELISA技术分别观察了活动期SLE外周血T细胞IL—2R表达及活动期与非活动期SLE患者血清sIL—2R水平的变化。实验结果表明,与正常对照组相比:(1)SLE患者外周血T细胞表面IL—2R数目显著减少(P<0.05);(2)血清sIL—2R水平(活动期及非活动期)则显著增高(p<0.01)。上述结果提示,测定T细胞表面IL—2R表达量及血清sIL—2R水平,对监视SLE患者的细胞免疫功能、病期变化及其在治疗决策上均有重要意义。T细胞表面IL—2R数量减少及血清sIL—2R水平增高可能是SLE免疫病理变化的一个重要机制。We observed the changes of LL-2R molecules on the peripheral blood lymphocytes in active SLE patients by cell receptor immunoradiometric assay and the concentrations of serum sIL—2R in active and inactive SLE patients by ELISA. The experimental results showed that the IL—2R molecules per T cell of SLE patients were significantly lower than that in controls (P<0.05), but the serum sIL—2R level(either in active or in inactives SLE)was significantly higher(P<0.01). Our observations suggest that measurements of IL—2R/sIL—2R levels appear to be very useful in monitoring cellular immune activation in vivo and may be beneficial in assessing disease activity and in making therapeutic scheme for patients with SLE. The changes of IL-2R/sIL-2R levels may be an important mechanism of immunopathology in SLE.

关 键 词：红斑锒疮 白细胞介素2 受体 

分 类 号：R593.241[医药卫生—内科学]