老年男性原发性高血压患者血清瘦素水平的研究  

Serum level of leptin in elderly male patients with essential hypertension

作　　者：刘杰[1] 苗懿德[1] 苟淑芹[2] 张颜秋[2] 

机构地区：[1]北京大学医学部附属人民医院老年医学科,北京市100044 [2]北京大学医学部附属人民医院核医学科,北京市100044

出　　处：《中国临床康复》2005年第3期89-91,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:国内外关于瘦素与高血压之间关系的研究不多,且结果也不一致。研究血清瘦素、体质量指数与血压的关系,探讨瘦素在老年男性原发性高血压发病中的作用。方法:选择2002-12/2003-7老年医学科住院的98例老年男性原发性高血压患者和40例正常对照者,采用放免法检测血清瘦素浓度,同时测定体质量指数(bodymassindex,BMI)、收缩压、舒张压,血清胆固醇及三酰甘油等指标。分析瘦素与其它各项指标的关系。结果:无论高血压组还是正常对照组,肥胖组(BMI>25kg/m2)血清瘦素浓度均显著高于非肥胖组(BMI<25kg/m2),P<0.01。高血压组血清瘦素水平(5.2±2.6)μg/L显著高于正常对照组犤(3.2±1.7)μg/L犦,(P<0.01),经协方差分析,校正BMI和年龄后,两组间血清瘦素水平差异仍有显著性意义。血清瘦素水平与年龄,BMI,收缩压,舒张压显著正相关,校正年龄及BMI后,瘦素浓度仍与收缩压(r=0.333,P<0.05)及舒张压(r=0.376,P<0.05)呈正相关。Logistic回归分析显示,瘦素及BMI的升高与高血压的发病密切相关。结论:血清瘦素与老年男性原发性高血压及肥胖密切相关。AIM:There are a few studies on the relationship between leptin and hypertension at home and abroad,and the results are not the same.The purpose of this study is to investigate the relationship of serum leptin and body mass index(BMI) with blood pressure(BP) so as to assess the role of leptin in the pathogenesis of essential hypertension(EH) in elderly males. METHODS:Ninety-eight elderly male EH patients and 40 normal controls hospitalized in the Department of Gerontology were selected from December 2002 to July 2003.Serum concentration of leptin was determined with radioimmunoassay.BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),cholesterol and triglyceride (TG) were measured simultaneously.The correlations between leptin and other parameters were analyzed. RESULTS:The serum concentration of leptin in the obese subjects (BMI >25 kg/m2) was significantly higher than that in the non-obese subjects(BMI< 25 kg/m2) hypertension group and normal control group with obesity in both the EH group and control group(P< 0.01).The serum concentration of leptin was significantly higher in the EH group [(5.2 ±2.6) μg/L] than in the control group[(3.2±1.7) μg/L](P< 0.01),there was still significant difference between the two groups when age and BMI were corrected by analysis of covariance.Serum concentration of leptin ent with age and BMI,leptin concentration was still positively correlated with SBP(r=0.333,P< 0.05) and DBP (r=0.376,P< 0.05).Logistic regression analysis showed that increases of leptin and BMI were significantly associated with the episode of hypertension. CONCLUSION: Serum concentration of leptin is positively related with EH and obesity in the elderly males.

关 键 词：瘦素 高血压 肥胖症 

分 类 号：R544.1[医药卫生—心血管疾病]