老年糖尿病患者胃排空功能的评估  

Function of gastric emptying in senile patients with diabetes mellitus

作　　者：魏立民[1] 王利群[2] 王世娟[1] 李香[1] 叶蔚[1] 马慧娟[1] 

机构地区：[1]河北省人民医院老年病三科,河北省石家庄市050051 [2]解放军军械工程学院医院,河北省石家庄市050051

出　　处：《中国临床康复》2005年第3期130-131,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:用13C辛酸呼气试验方法检测老年2型糖尿病患者胃排空功能,并分析其相关因素。方法:2002-07/2003-01河北省人民医院老年病三科住院2型糖尿病患者共148例。纳入标准:符合WHO1999年糖尿病诊断标准;排除标准:胃肠道器质性病变、严重肝、肾、心脑血管疾病者。将符合上述标准的2糖尿病患者31例设为糖尿病组,年龄61～74岁。选择同期体检健康的老年自愿者19例为对照组,年龄60～73岁。给予糖尿病患者及对照组老年人13C辛酸试验餐,检测呼气样品,计算患者胃半排空时间(half-emptyingtime,T1/2)、延迟相时间(lagphasetime,Tlag);同时记录患者年龄、性别、病程、体质量指数(bodymassindex,BMI)、症状得分,检测患者空腹血糖、餐后血糖、糖化血红蛋白(HbA1c),并与T1/2进行相关分析。结果:糖尿病患者胃排空延迟发生率及胃T1/2,Tlag犤48%,(191.33±64.77),(124.56±55.63)min犦明显高于对照组犤10%,(111.58±22.66),(88.74±20.33)min犦(χ2=7.525,P=0.006;t=3.858,3.523,P<0.01);患者T1/2与空腹血糖、HbA1c,BMI有相关关系(r=0.54,0.16,0.43,P=0.006,0.024,0.036),而与年龄、病程、性别、症状得分、餐后血糖无明显相关性(P>0.05)。结论:老年2型糖尿病患者可能存在胃排空时间延迟;空腹血糖。AIM:To investigate the gastric emptying function with 13C octanoic acid breath test in senile patients with type 2 diabetes mellitus(DM), and analyze the related factors. METHODS:There were 148 patients with type 2 DM,who were hospitalized in the Third Department of Geriatrics, Hebei Provincial People's Hospital during July 2002 to January 2003.Thirty-one of them(DM group),aged 61 to 74 years old, who were in accordance with the 1999 WHO diagnostic norm and without organic lesion of gastrointestinal tract,severe liver,kidney,cardiovascular and cerebrovascular diseases,were involved in the study.Other 19 health subjects,aged 60 to 73 years old,at the same period were selected. All the subjects ingested a test meal with 13C octanoic acid. Breath samples for 13C measurement were collected, and the half-emptying time(T1/2), lag phase time(Tlag) were calculated.The age, sex,course,body mass index(BMI),symptom score were recorded,fasting blood glucose,postprandial blood glucose and glycosylated hemoglobin A(HbA1c) were measured and the relationship with T1/2 was analyzed respectively. RESULTS:The incidence rate of delayed gastric emptying,T1/2 and Tlag in the DM group[48%,(191.33±64.77),(124.56±55.63) minutes] were obivously higher than those in the control group[10%,(111.58 ±22.66),(88.74±20.33) minutes](χ2=7.525,P=0.006;t=3.858,3.523,P< 0.01).The T1/2 was correlated with fasting blood glucose, HbA1c and BMI(r=0.54,0.16,0.43, P=0.006,0.024,0.036),but had no obvious relation with age, course, sex,symptom score and postprandial glucose (P >0.05). CONCLUSION:The gastric emptying time in senile type 2 DM patients may be significantly delayed; and fasting blood glucose, HbA1c and BMI are the influencing factors for gastric empting.

关 键 词：糖尿病 非胰岛素依赖型/并发症 胃排空 胃肌轻瘫/病因学 

分 类 号：R587.1[医药卫生—内分泌]