聚醚桥连二异羟肟酸配合物催化PNPP水解的动力学研究  

The Kinetic Study on Polyether-bridged Dihydroxamic Acids Binuclear Complexes as Mimic Hydrolytic Enzyme CatalyzePNPP Hydrolysis

作　　者：雷光东[1] 蒋维东[2] 李建章[2] 李鸿波[3] 徐斌[2] 刘富安[2] 秦圣英[3] 

机构地区：[1]内江师范学院化学与生命科学系,四川内江641112 [2]四川理工学院化学系,四川自贡643000 [3]四川大学化学学院,成都610064

出　　处：《四川大学学报（自然科学版）》2005年第1期143-148,共6页Journal of Sichuan University(Natural Science Edition)

基　　金：四川省教育厅重点科研项目(2003A182);四川理工学院校级科研课题(2004ZR009)

摘　　要：将4种聚醚桥连二异羟肟酸过渡金属铜(II)、锌(II)、钴(II)和锰(II)配合物作为仿水解酶模型催化羧酸酯(PNPP)水解.探讨了聚醚桥连二异羟肟酸过渡金属配合物催化PNPP水解的动力学和机理;提出了配合物催化PNPP水解的动力学模型.结果表明,在25℃条件下随着缓冲溶液pH值的增大,配合物催化PNPP水解速率提高,并表现出好的催化活性.Four polyether-bridged dihydroxamic acids transition-mental complexes have been used as mimic hydrolytic enzyme model catalyzing carboxylic acid esters (PNPP) hydrolysis. Thekinetics and the mechanism on PNPP hydrolysis catalyzed by these complexes were investigated. The kinetic mathematical model of PNPP cleavagecatalyzed bythese complexes was proposed. The results showed that the rate for the PNPP hydrolysis catalyzed was increased following the increase of pH of the buffer solution; four complexes exhibited high activity inthe PNPP catalytichydrolysis.

关 键 词：聚醚桥连二异羟肟酸 过渡金属配合物 PNPP水解 动力学 

分 类 号：O643[理学—物理化学]