对葛根素与葛根黄酮体内动力学关系的探讨——兼论中药药代动力学的研究方法  

Exploration of Relationship between in vivo Dynamics of Puerarin and Flavone of Root of Kudzu Vine - and a Discussion on Study Method of Pharmacokinetics of Chinese Medicines

作　　者：杜力军[1] 邢东明[1] 炎彬[1] 卢弘[1] 赵玉男[1] 谢伟东[1] 雷帆[1] 陶佳林[1] 

机构地区：[1]清华大学生物科学与技术系药物药理研究室,北京100084

出　　处：《世界科学技术-中医药现代化》2004年第6期26-30,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：清华大学基础研究基金(JC2000050):中药药代动力学方法学研究

摘　　要：中药药代动力学用分析的方法,对中药多成分的复杂体系的体内动力学过程进行综合表征。探究一个或若干成分在多大程度上能够代表或表征总成分的体内动力学过程,将是研究的关键。本文以所做的工作为基础,结合有关文献,以葛根素与葛根黄酮的体内药代动力学为例,对该问题进行了较为深入讨论。结果表明:葛根素的体内动力学过程与葛根黄酮在许多方面接近,可以用其来表征葛根黄酮的体内动力学过程。同类未定性成分体内动力学特征与葛根素有较好的相关性,可以共同来表征葛根黄酮的药代特征。The pharmacokinetics of Chinese medicines requires that the in vivo dynamics process of the complex system of multi - components of Chinese medicines should be comprehensively characterized by analytical methods. It is the key to study to what extent one component or some more can represent or characterize the process of in vivo dynamics of the total components. This article gives a rather deep exploration of this subject on the basis of the authors' study, in combination with related literatures and taking the in vivo dynamics of puerarin and the flavone of the root of kudzu vine as an example. The result shows that the process of the in vivo dynamics of puerarin is quite similar to that of the flavone of the root of kudzu vine and therefore, the former is able to characterize the latter. And the characteristics of in vivo dynamics of non - definite components of the latter's like are greatly interrelated and can characterize the latter's pharmacokinetics as well.

关 键 词：体内动力学 葛根素 葛根黄酮 中药 体内药代动力学 酮体 相关性 成分 综合 

分 类 号：R681.2[医药卫生—骨科学] R979.1[医药卫生—外科学]