基于Ag/AgCl丝双涂膜曲马多离子选择电极的研制与应用  

Preparation and Application of a Doubly Coated Membrane Tramadol Ion-selective Electrode Based on Ag/AgCl Wire

作　　者：黄超伦[1] 修荣[1] 刘智勇[1] 李迎春[1] 孟程军[1] 

机构地区：[1]河北医科大学药学院,石家庄050017

出　　处：《分析科学学报》2005年第1期48-50,共3页Journal of Analytical Science

摘　　要：以Ag/AgCl丝为基体依次外涂含0.1mol/LKCl的琼脂凝胶膜及含四苯硼 曲马多缔合物的PVC膜,制备了一种双涂膜曲马多离子选择电极。该电极的线性范围为2.5×10-5～1.0×10-2mol/L,斜率为57.3mV/pc,检出限为1.6×10-5mol/L,性能稳定,体积微小,能用于盐酸曲马多制剂的含量测定。A doubly coated membrane tramadol ion-selective electrode was prepared after a Ag/AgCl wire was coated a layer of agar gel membrane containing 0.1 mol/L KCl and a layer of PVC membrane containing tramadol-tetraphenylboron ion-pair complex on its surface successively. The linear response range of the electrode was 2.5×10^(-5)～1.0×10^(-2 )mol/L. The detection limit was 1.6×10^(-5)mol/L and the slope was 57.3 mV /decade(25℃).The electrode had good stability and a micro volume and could be used for potentiometric determination of tramadol tablets directly. The results obtained agreed with those determined by the method in the Chinese Pharmacopoeia.

关 键 词：离子选择电极 曲马多 双涂膜 

分 类 号：O657.14[理学—分析化学]