前药转换酶/前药体系的研究进展  

Progress in study of prodrug-activating enzyme/prodrug system

作　　者：陈建发[1] 黄宗海[1] 

机构地区：[1]第一军医大学珠江医院普通外科,广东广州510282

出　　处：《肿瘤防治杂志》2004年第4期417-421,共5页China Journal of Cancer Prevention and Treatment

摘　　要：前药转换酶 /前药体系是自杀基因疗法的核心 ,关系到自杀基因疗法的成败 ,近年来得到深入研究。就前药转换酶 /前药体系的种类、作用机制和体外。The prodrug-activating enzyme/prodrug system is the most important component of suicide gene therapy,in which further investigations have been carried out.The varieties,mechanism and in vitro/ in vivo effect of popular enzyme/prodrug systems have been reviewed herein.

关 键 词：肿瘤/治疗 基因疗法 药物前体 转导 遗传 转染 综述文献 

分 类 号：R456[医药卫生—治疗学]