乳胶过敏发病机制的研究  

The study on pathogenesis of latex allergy

作　　者：李凝[1] 陈波[2] 许以平[3] 王建华[3] 吴祖群[3] 邹寒冰[3] 

机构地区：[1]山东省青岛市市立医院免疫风湿科,266011 [2]山东省青岛市市立医院放射科,266011 [3]上海仁济医院分子生物学实验室

出　　处：《中华劳动卫生职业病杂志》2005年第1期50-52,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：目的研究乳胶过敏的发病机制,探讨其在职业病防治中的意义。方法统计分析上海仁济医院过敏性疾病防治中心651例门诊患者常见过敏原皮肤点刺试验(SPT)结果;再按门诊号随机选择64例乳胶SPT阳性患者,并以30例无过敏性疾病及其家族史的正常人作为对照,采用纸片法ELISA和Western-blot测定血清中乳胶特异性IgE(sIgE)。结果门诊过敏性疾病患者乳胶SPT的阳性率(37.5%)较高;乳胶过敏高危人群乳胶sIgE的阳性率(39%)高于非高危人群(16%)和正常对照(0%),差异有统计学意义(P<0.05,P<0.01);过敏患者血清可与乳胶手套浸出液中的多种成分反应。结论乳胶是过敏性疾病患者常见致敏原之一,IgE介导的速发反应是乳胶过敏的常见形式之一,高危人群应进行乳胶过敏检查,以便适当进行职业防护和日常保护。Objective In order to study the pathogenesis of latex allergy and the significance in the prevention and cure of occupational diseases. Methods 651 cases in the out-patient department were tested with skin prick test(SPT),and the specific IgE(sIgE) to latex were detected by means of disk ELISA and Western-blot. ~Results It was found that the positive rate of latex SPT(37.5%) and sIgE(31.25%) were rather higher in patients in comparison with those of the normal.The positive rate of latex sIgE was much higher in the high-risk group than that of the low-risk group and the normal.The serum of the patients can react with multi-bands in the latex glove extracts. Conclusion The prevelance of latex allergy is rather high,this disease is mediated by IgE.The people in high-risk should be tested by latex allergy in order to take proper occupational and daily protection.

关 键 词：过敏性疾病 患者 常见 乳胶手套 发病机制 高危人群 门诊 反应 研究 成分 

分 类 号：R593.1[医药卫生—内科学] R197[医药卫生—临床医学]