严重创伤MODS高血糖患者内毒素、胰岛素抵抗和胰岛素分泌指数变化  

The Changes of the Levels of the Blood Endotoxin Insulin Resistance in Trauma MODS Patients with High Blood Glucose

作　　者：祝仲珍[1] 王占科[1] 熊小平[1] 杨莉萍[1] 陈致怀[1] 王志[1] 

机构地区：[1]解放军第九四医院,江西南昌330002

出　　处：《实用中西医结合临床》2005年第1期4-5,共2页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨严重创伤多脏器功能衰竭(MODS)高血糖患者血内毒素、胰岛素抵抗和胰岛素分泌功能变化及其临床价值。方法:观察创伤MODS高血糖和正常血糖组死亡率变化,测定创伤MODS高血糖和正常血糖组血内毒素、空腹血糖、空腹胰岛素等含量,计算稳态模式评估法胰岛素抵抗指数(HOMA-IR)和胰岛素分泌指数(HOMA-β)。结果:创伤MODS高血糖组病死率明显高于创伤MODS正常血糖组(P<0.01);创伤MODS高血糖组血内毒素含量、HOMA-IR指数明显高于创伤MODS正常血糖组,创伤MODS高血糖组HOMA-β指数明显低于创伤MODS正常血糖组。结论:创伤MODS合并高血糖患者预后不良,内毒素在创伤MODS患者高血糖症中,发挥重要作用。Objective:To study the signification of the The changes of the levels of the blood endotoxin,insulin resistance and insulin secretion in trauma MODS patients with high blood glucose.Methods:The death rates of all the groups are observed.The blood endotoxin,fasting glucose,insulin in all the groups are determined,and the indexes of HOMA-IR and HOMA-βare calculated.Results:The death rates of the trauma MODS patients with high blood glucose is higher than that with normal blood glucose.The levels of blood endotoxin and HOMA-IR in trauma MODS patients with high blood glucose are higher than that with normal blood glucose;The levels of the HOMA-βin trauma MODS patients with high blood glucose are higher than that with normal blood glucose.Conclusion:The trauma MODS patients with high blood glucose represents a bad prognosis,the blood endotoxin plays a important roles on the glycemia symptom in the trauma MODS patients.

关 键 词：创伤 MODS 内毒素 胰岛素抵抗 胰岛素分泌 空腹高血糖 

分 类 号：R641[医药卫生—外科学]