超声血流动力学与血清标志物评价婴儿肝炎综合征肝纤维化程度  

Assessment of the degree of hepatic fibrosis using ultrasonography and serology in infant hepatitis syndrome

作　　者：李智贤[1] 梁淡湄[2] 王琳琳[2] 何云[1] 马韵[3] 杨红[1] 韦康来[3] 

机构地区：[1]广西医科大学第一附属医院超声科,广西南宁530021 [2]广西医科大学第一附属医院儿科,广西南宁530021 [3]广西医科大学第一附属医院病理科,广西南宁530021

出　　处：《中国医学影像技术》2005年第1期83-85,共3页Chinese Journal of Medical Imaging Technology

基　　金：广西教育厅科研项目 (A 990 9)资助。

摘　　要：目的　探讨超声血流动力学与血清肝纤维化标志物对婴儿肝炎综合征 (IHS)肝纤维化程度的临床应用价值。方法　超声检测 41例IHS患儿肝脏血流动力学 ,并检测血清肝纤维化标志物 ,按病理肝纤维化程度分组 ,进行单因素方差分析和相关分析。结果　肝固有动脉收缩期峰值速度 (PSV)和阻力指数 (RI)、血清透明质酸 (HA)测值在轻、中、重度肝纤维化组逐渐增高 ;与肝纤维化程度呈正相关 (r分别为 0 .717、0 .745和 0 .712 ,P =0 .0 0 1) ;HV多普勒频谱波形改变与肝纤维化程度有较好的相关性 (r =0 .783 ,P <0 .0 0 1)。结论　PHA的PSV和RI、血清HA浓度、HV多普勒频谱波形改变是反映IHS肝纤维化程度较敏感的指标。Objective To evaluate the practical value of hemodynamics on ultrasonography and serum fibrosis markers in assessing liver fibrosis in the patients with infant hepatitis syndrome (IHS) Methods Forty one cases of IHS were examined by ultrasonography, which was compared with the serum fibrosis indexes determined by radioimmunoassay. All cases with liver fibrosis were staged through liver biopsy, which were clarified into mild, moderate and severe groups based upon liver histopathological findings. Comparative and correlative analyses were carried out. Results PSV and RI of the proper hepatic arteries (PHA), serum hyaluronic acid (HA) showed a consecutive increase from mild to severe hepatic fibrosis and closely positive correlations with hepatic fibrosis in IHS groups ( r =0.717, 0.745 and 0.712, respectively, P =0.001), and Doppler waveform of HV was also significantly correlated with the degree of hepatic fibrosis in IHS groups ( r =0.783, P <0.001). Conclusion PSV and RI of PHA, serum HA are sensitive indicators in staging hepatic fibrosis in patients with IHS.

关 键 词：婴儿肝炎综合征 肝纤维化 多普勒超声检查 血流动力学 

分 类 号：R725.7[医药卫生—儿科] R445.1[医药卫生—临床医学]