亚砷酸制剂研究进展  

Recent Development of Scientific Researches on Arsenics

作　　者：辛娟[1] 王远亮[1] 郭莉霞[1] 朱久进[1] 

机构地区：[1]重庆大学生物工程学院生物力学与组织工程教育部重点实验室,重庆400030

出　　处：《重庆大学学报（自然科学版）》2005年第1期157-161,共5页Journal of Chongqing University

基　　金：国家自然科学基金资助项目(30270395);国家高技术研究发展计划(863计划)资助项目(2003AA32X210)

摘　　要：针对近年来世界上许多国家或地区相继报道长期暴露于含砷饮用水中的个体出现不同程度的砷中毒症状,或因砷而引起的多种疾病等状况;而我国中医却应用砷剂治疗多种血液肿瘤和实体瘤,特别是治疗急性早幼粒白血病(APL)已取得了较好疗效。从治病性和致病性两个角度分别讨论了主要包括亚砷酸在内的多种含砷化物的生物学毒性,对人体各系统的损害和抗肿瘤作用,为临床应用含砷制剂治疗癌症提供借鉴,同时展望了砷制剂的临床应用前景。In recent yuars,environmental arsenic contamination is a major problem in many parts of the world. There are many reports from many nations on human exposure to arsenic in drinking water has been linkedto various diseases and chronic arsenic poisoning symptoms . Though arsenic has been known as a poison for thousands of years, there have long been reports of benfical effects.Chinese medicine has used arsenic as a medicinal for thousands of years,especially studies have identified arsenic trioxide as a powerful and dramatic therapy for acute promyelocytic leukaemia(APL),which suggested many scholor use this drug to cure various tumors.

关 键 词：亚砷酸制剂 生物学毒性 致病性 临床应用 抗肿瘤 

分 类 号：R962[医药卫生—药理学] R73[医药卫生—药学]