应力导致的细胞内信号转导和基因表达变化  

Effect of Mechanical Stress on Cellular Signal Transduction and Gene Expression

作　　者：尚娟芳[1] 王远亮[1] 唐丽灵[1] 牛旭锋[1] 

机构地区：[1]重庆大学生物工程学院生物力学与组织工程教育部重点实验室,重庆400030

出　　处：《重庆大学学报（自然科学版）》2005年第1期162-165,共4页Journal of Chongqing University

基　　金：国家自然科学基金资助项目(19872080)

摘　　要：阐述了应力与细胞的紧密关系。综述了应力作用细胞后引起的生化反应及其细胞骨架介导的信号转导和相关基因表达的变化,系统列举了一些应力诱导的基因表达变化,如即早基因、细胞因子、酶、胞外基质分子等;并针对细胞应力响应,提出了目前这一领域存在的一些问题,希望应力与细胞响应的分子机制得到进一步发展,为解决应力引起的生物体生理和病理变化提供理论基础。The close relationship between stress and cell is summarized. Literatures at home and abroad are inspected. Biochemical reaction cause for stress acting on cell and changes of cytoskeleton signal transduction, correlation gene expression,are reviewed. Then, some gene expression changes induced by stress is systematically enumerated, such as immediate gene productions, cellular factors, enzymes, extracellular matrix molecules,etc. Finally, aiming at cellular stress response, some problems in the area are put forwarded, the molecular mechanism of stress and cellular response is expected to gain a step progress, and thoughts are offered to settle the physio-pathology changes of organism caused by stress.

关 键 词：应力 基因表达 信号转导 

分 类 号：Q819[生物学—生物工程]