血清肌钙蛋白I与老年心力衰竭患者心肌损伤和心脏事件关系的临床研究  

Clinical study of serum cardiac troponin I on myocardial cell injury and heart events in patients with senile congestive heart failure

作　　者：薛红新[1] 赵思义[1] 程训民[1] 李淑玲[1] 周鸿雁[1] 王敬雨[1] 

机构地区：[1]安徽省淮北市人民医院,安徽淮北235000

出　　处：《中国现代医学杂志》2005年第2期275-277,共3页China Journal of Modern Medicine

摘　　要：目的探讨老年心力衰竭患者血清肌钙蛋白I(cTnI)测定与心肌损伤和心脏事件的关系。方法应用微粒子化学发光法对30例心功能II级,18例心功能III级,8例心功能IV级的老年心衰患者和30例心功能正常的老年患者进行血清cTnI检测,并对52例老年心衰患者的远期心脏事件随访至少12个月,分析cTnI与心脏功能和远期心脏事件的关系。结果56例老年心衰组患者中有26例cTnI升高,其中心功能III级和IV级患者血清cTnI均比心功能II级明显增高(P<0.01)。30例老年对照组中血清cTnI仅1例升高。52例老年心衰患者远期随访,随访时间为(16±4)个月。老年心衰患者中cTnI升高组心脏事件发生例次较cTnI正常组明显增多(P<0.01)。结论血清cTnI不但是心衰时具有高度敏感性和特异性的心肌损伤标记物,也是反映心衰严重程度和预后的一个重要生化指标。To investigate the correlation between serum cardiac troponin I (cTnI ) and myocardial cell injury and heart event in patients with senile congestive heart failure (CHF). Serum cTnI in 56 patients with CHF and 30 patients without heart disease were measured by the method of microcorpuscle chemiluminescence. Late heart event were followed -up with the duration of at least 12 months. The correlation between cTnI and cardiac injury and heart event were studied. In 26 of 56 patients with senile CHF and only 1 of 30 patients without CHF, serum level of cTnI was elevated. In addition, serum level of cTnI was elevated significantly in patients of New York Heart Association (NYHA) class III and class IV than those in NYHA class II (P <0.01). Further, the late follow-up [(16±4) month] was finished in 52 patients with senile CHF. The heart events in patients of elevated cTnI were higher than those in patients of normal cTnI (P <0.01). [Conclusions] Serum level of cTnI is not only a highly sensitive and specific marker for myocardial cell injury, but also an important biochemical parameter reflecting the severity and prognosis of CHF.

关 键 词：心脏事件 心力衰竭 肌钙蛋白Ⅰ 

分 类 号：R541.6[医药卫生—心血管疾病]