马蔺子素脂质体的体外药剂学性质研究  

Pharmaceutical characteristics of irisquinone liposomes in vitro

作　　者：孙锋[1] 戴俊东[1] 吕万良[1] 张烜[1] 李德华[1] 张强[1] 

机构地区：[1]北京大学药学院药剂学系,北京,100083

出　　处：《中国新药杂志》2005年第1期57-61,共5页Chinese Journal of New Drugs

摘　　要：目的:研究马蔺子素脂质体的体外药剂学性质。方法:采用反相蒸发(REV)法制备马蔺子素脂质体,建立马蔺子素的HPLC含量测定法。检验其各项物理化学性质,考察其稳定性与体外释放。结果:马蔺子素脂质体包封率达到98%以上,粒径在100nm左右,3个月内稳定性良好,体外释放48h不超过30%。结论:所制得的马蔺子素脂质体的物理化学性质优良,稳定性良好,体外释放较缓慢。Objective: To characterize the irisquinone liposomes in vitro. Methods: Irisquinone liposomes prepared by the REV technique were quantified by HPLC. The physicochemical characteristics including the stability and drug release in vitro were determined. Results: The encapsulation rate of irisquinone achieved more than 98 percent with the particle size around 100nm. Irisquinone Iiposomes remained stable for 3 months and showed a drug release rate of less than 30% within 48 hours in vitro. Conclusion :The stable irisquinone liposomes have advantages of sustained release.

关 键 词：马蔺子素 脂质体 体外释放 稳定性试验 

分 类 号：R979.19[医药卫生—药品] R944.9[医药卫生—药学]