彩色多普勒超声观测大鼠内皮损伤后血管内膜增生过程  

Doppler Ultrasonic Evaluation on Intimal Hyperplasia after De-endothelialization in Rat Arteries

作　　者：聂磊[1] 韩梅[1] 温进坤[1] 

机构地区：[1]河北医科大学基础医学研究所生化室河北省医学生物技术重点实验室,石家庄市050017

出　　处：《中国超声医学杂志》2005年第2期92-95,共4页Chinese Journal of Ultrasound in Medicine

基　　金：国家自然科学基金 (No. 30 2 70 4 99);河北省自然科学基金 (No. 30 3454)资助项目

摘　　要：目的　建立大鼠胸腹主动脉内皮剥脱模型 ,观察血管再狭窄发生过程中血管内膜增生的动态变化 ,以探讨彩色多普勒超声在血管再狭窄中的诊断价值。方法　应用高频超声检测大鼠主动脉胸段内皮剥脱后血管再狭窄过程中不同时间内径、血流速度以及阻力指数并与病理指标相对照。结果　大鼠胸腹主动脉内皮剥脱后 ,血管内膜增生 ,管腔狭窄 ,血流速度减慢 ,血管阻力指数增高。结论　超声指标和病理指标相互印证 ,为无创动态观察再狭窄的发病过程及治疗效果提供了新的实验依据和手段。Objective To evaluate the dynamics of Doppler ultrasound in restenosis after de-endothelialization.The restenosis model was established by denuding the rat aortic endothelium and the dynamic changes of intima hyperplasia was detected.Methods Changes of the inner diameters,hemodynamics,pulsatile index (PI) and resistance index (RI) in restenosis after de-endothelialization at different times were observed with high frequency ultrasound,and compared with pathology.Results The luminal diameters,the maximal and minimal blood velocities were decreased in restenosis,whereas the pulsatile index (PI) and resistance index (RI) were increased.Image analysis showed in pathology and ultrasound.Conclusions These results indicated that Doppler ultrasound technique could be used to find out the mechanisms of episode and the therapeutic efficacy of restenosis after de-endothelialization.

关 键 词：大鼠 血管内膜增生 剥脱 内皮损伤 血管再狭窄 彩色多普勒超声 腹主动脉 过程 结论 手段 

分 类 号：R445.1[医药卫生—影像医学与核医学]