N-烷基-3-吡咯酮类化合物的合成  

Synthesis of N-Alkyl-3-pyrrolidinones

作　　者：李乐平[1] 段学民[1] 陈立功[1] 

机构地区：[1]天津大学药物科学与技术学院,天津300072

出　　处：《精细化工》2005年第2期158-160,共3页Fine Chemicals

摘　　要：通过合成正己基、正辛基、苄基3种不同取代基的N 烷基 3 吡咯酮,对N 烷基 3 吡咯酮类化合物的合成方法进行了研究。以胺类化合物为原料,与丙烯酸甲酯进行Michael加成,所得一次加成物再与氯乙酸甲酯反应,其产物在甲醇钠存在下进行Dieckmann环合,最后在酸性条件下脱羧,高收率得到N 正己基 3 吡咯酮,N 正辛基 3 吡咯酮和N 苄基 3 吡咯酮,总收率分别为73%,81%和78%。The synthetic method of N-alkyl-3-pyrrolidinones was studied through the syntheses of hexyl,octyl and benzyl substituted pyrrolidinones.The target compounds were obtained in high yields through the following processes.Michael conjugative additions were conducted with amines and methyl acrylate,the single adducts were treated with methyl chloroacetate,and then,Dieckmann cyclocondensation of the obtained compounds was carried out in the presence of sodium methoxide,followed by decarboxylation in acid.Yields of N-hexyl,N-octyl and N-benzyl-3-pyrrolidinone were 73%,81% and 78% respectively.

关 键 词：吡咯酮 MICHAEL加成 Dieckmann环合 脱羧 

分 类 号：O626.13[理学—有机化学]