模拟飞船应急返回时高+Gx对大鼠学习记忆功能的影响  

Effects of High +Gx during Simulated Spaceship Emergency Return on Learning and Memory in Rats.

作　　者：徐志鹏[1] 孙喜庆[1] 刘挺松[1] 吴斌[2] 张舒[1] 吴萍[2] 

机构地区：[1]第四军医大学航空航天医学系航空航天生物动力学教研室,陕西西安710032 [2]航天医学工程研究所,北京100094

出　　处：《航天医学与医学工程》2005年第1期1-5,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金(39800158)

摘　　要：目的探讨模拟飞船应急返回时高+Gx对大鼠学习记忆功能的影响。方法32只雄性SD大鼠随机分为对照组、+15Gx/180s超重组、7d模拟失重组及7d模拟失重后再+15Gx/180s超重组,每组8只。采用Y 型迷宫实验和避暗实验观察应激后不同时间大鼠学习记忆功能的变化。结果在Y 型迷宫实验中,模拟失重后再超重组大鼠正确率在暴露后各时间点较对照组均显著降低(P<0.01),反应时均显著延长(P<0.01);与+15Gx超重组和模拟失重组相比,仅在暴露后即刻正确率显著降低(P<0.05),反应时显著延长(P<0.05)。在避暗实验中,模拟失重后再超重组大鼠总时间在暴露后即刻和1d较对照组均显著增加(P<0.01),潜伏期在暴露后各时间点均显著缩短(P<0.01),错误次数均显著增加(P<0.01);与+15Gx超重组相比,总时间在暴露后即刻和1d均显著增加(P<0.05);与模拟失重组相比,总时间、错误次数仅在暴露后即刻显著增加(P<0.05)。结论+15Gx/180s超重和7d模拟失重可引起大鼠学习记忆能力下降,7d模拟失重可以加重+Gx超重过载对学习记忆功能的影响。Objective To observe the effects of high +Gx during simulated spaceship emergency return on learning and memory in rats. Method Thirty two male SD rats were randomly divided into control group, 7 d simulated weightlessness group, +15 Gx/180 s group and +15 Gx/180 s exposure after 7 d simulated weightlessness group, with 8 rats in each group. The changes of learning and memory in rats were measured after stresses by means of Y-maze test and step-through test. Result In Y-maze test, as compared with control group, percentage of correct reactions decreased significantly(P<0.01) and reaction time increased significantly(P<0.01) in hypergravity after simulated weightlessness group at all time after stress;as compared with +15 Gx group or simulated weightlessness group, percentage of correct reactions decreased significantly(P<0.05) and reaction time increased significantly(P<0.05) immediately after stress. In step-through test,as compared with control group,total time increased significantly (P<0.01) in hypergravity after simulated weightlessness group at 1 d after stress;latent time decreased significantly(P<0.01)and number of errors increased significantly (P<0.01) at all the time after stress. As compared with +15 Gx group, total time increased significantly (P<0.05) immediately, 1d after stress. As compared with simulated weightlessness group, total time and number of errors increased significantly (P<0.05) immediately after stress. Conclusion It is suggested that+15 Gx/180 s and simulated weightlessness may affect the ability of learning and memory of rats . Simulated weightlessness for 7 d can aggravate the effect of +Gx on learning and memory ability in rats.

关 键 词：失重模拟 正加速度 +GX 学习 记忆 脑功能 

分 类 号：R852.21[医药卫生—航空、航天与航海医学]