胸背向过载作用后猴脑部损伤CT灌注成像的初步研究  

The preliminary study of CT cerebral perfusion imaging on the brain injury of the high +Gx in Rhesus

作　　者：费军 吴斌[2] 张朝利 田向东[2] 周翠萍 赵德明[3] 

机构地区：[1]解放军第三六医院放射科,北京100101 [2]北京航天医学工程研究所 [3]北京中国农业大学动物医学院

出　　处：《中华放射学杂志》2005年第2期127-130,共4页Chinese Journal of Radiology

摘　　要：目的探讨CT脑灌注成像对胸背向过载过载(+Gx)作用下猴脑部损伤的诊断价值。方法7只健康雄性成年恒河猴随机表法随机分为对照组(2只)和+15Gx组(5只),+15Gx组在动物离心机上承受+15Gx峰值的抛物线形过载曲线作用;应用CT脑灌注成像分别观察+Gx作用前和作用后2h、24h、1周后猴脑血流的改变,同时行病理(光学显微镜、电子显微镜)检查。结果+15Gx过载作用后2h、24h大脑呈缺血性改变,1周后血流灌注基本恢复正常;光学显微镜下显示大脑皮层锥体细胞出现轻度的缺血性萎缩,电子显微镜下表现为核染色质聚集成团块状边集,胞质内线粒体嵴轻度紊乱。结论模拟飞船应急返回高过载可引起猴脑缺血性改变,CT脑灌注成像可提供有价值的诊断信息。Objective To explore the diagnostic value of CT cerebral perfusion imaging on the brain injury of the high +Gx in Rhesus. Methods Seven healthy male adult Rhesus were randomly divided into control group and +15 Gx group. The +15 Gx group underwent parabolic G curve in animal centrifuge. The animals were all examined by CT cerebral perfusion before +Gx exposure, 2 h, 24 h, and 1 week after ^+Gx exposure. The results were compared with pathologic examination. Results 2 h and 24 h after +15 Gx exposure, brain ischemia was showed on CT cerebral perfusion imaging. After 1 week, the brain ischemia was almost recovered to normal. Mild ischemic atrophy was observed in pyramidal neurons in cerebral cortex by light microscopy. Electron microscopic observation showed chromatin marginating and mitochondria cristae blurring in pyramidal cells after +Gx overload. Conclusion High G from simulating spaceship emergency return can cause ischemic injuries of the brain in Rhesus, and CT brain perfusion imaging can provide valuable diagnostic information.

关 键 词：CT脑灌注成像 改变 缺血性 脑部损伤 轻度 +GX CT灌注成像 高过载 显示 集成 

分 类 号：R816.1[医药卫生—放射医学]