老年高血压合并腔隙性脑梗塞患者胰岛素抵抗的临床研究  

Clinical Study on the Relationship Betwen Insulin Resistance and Elderly Hypert ension Patients with Lacunar Celebral Infarction

作　　者：钟忠辉[1] 夏向南[1] 张丹凤[1] 黄敏[1] 翁向群[1] 徐军霞[1] 林鹏飞[1] 

机构地区：[1]中国人民解放军南京军区福州总医院老年一科,邮政编码福州350025

出　　处：《微循环学杂志》2005年第1期52-53,共2页Chinese Journal of Microcirculation

摘　　要：目的 :研究胰岛素抵抗 (IR)与高血压合并腔隙性脑梗塞患者之间的关系。方法 :选取 2 8例高血压合并腔隙性脑梗塞患者作为研究对象 ,测定血糖(FPG)、胰岛素水平 (FINS)、C 肽、总胆固醇 (CH)、甘油三酯 (TG)。另 2 8例正常健康老年人作为对照组。同时计算胰岛素敏感指数 (ISI)。结果 :高血压合并腔隙性脑梗塞患者FINS、C 肽水平显著高于对照组 (P <0 .0 1) ,其ISI较对照组显著降低 (P <0 .0 1)、脑梗死组FINS显著高于正常对照组 (P <0 .0 5) ,其ISI较正常对照组显著降低 (P <0 .0 5)。结论 :老年高血压合并腔隙性脑梗塞患者存在IR ,IR作为腔隙性脑便塞独立危险因素应引起高度重视。Objective:To sutdy the relationship between insulin resistance( IR) and lacunar cerebral infarction with elderly hypertension patients.Method:56 patients were divided into two groups,28 cases elderl y hypertension patients with celebral lacunar infarction,the other 28 cases nor mal control.Their fasting plasma glucoses,serum c-Ps,insluin levels,chol esteral and triglyceride before breakfast were measured.Their insulin sensitivit y indexes(ISI) were compared each other.Results:Insluin、C-Ps are signsificantly higher and ISI is sig nificantly lower in patients with cerebral lacunar infarction than that of norma l cont rols(P<0.01).Conclusion:IR exists in cerebral lacunar in farction with elderly hypertension patients and it is an important risk factor f or cerebral lacunar infarction.

关 键 词：胰岛素抵抗 老年高血压 腔隙性脑梗塞 患者 临床研究 代偿 脂质代谢紊乱 合并 产生 IR 

分 类 号：R587[医药卫生—内分泌] R743.33[医药卫生—内科学]