益妇宁软胶囊对去势大鼠免疫功能的影响  

Effects of Yifuning Soft Gelatin Capsules on Immune Function of Ovariectomized Rats

作　　者：肖炜[1] 马云[2] 邓虹珠[3] 魏连波[1] 

机构地区：[1]南方医科大学珠江医院中医科,广州510282 [2]南方医科大学南方医院药局,广州510515 [3]南方医科大学中医系,广州510515

出　　处：《中药新药与临床药理》2005年第1期27-29,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：军队医药卫生科研基金课题(编号2000B01);广东省中医药局项目(编号400001)。

摘　　要：目的 观察益妇宁软胶囊 (Y FN )对去势大鼠免疫功能的影响。方法 50只 SD 雌性大鼠随机分为 5组:正常对照组、模型对照组、己烯雌酚片组、YFN 大、小剂量组。给药 4周后用放射免疫法测定大鼠血清雌二醇( ) E2 、白细胞介素 2(IL -2)水平,放射配基受体结合分析法测定脾细胞雌激素受体( ),光镜下观察胸腺病理组织学变 ER化,测定大鼠体重及脏器指数。结果 Y FN 能明显升高大鼠去势后降低的血清 E2、IL -2水平 (P <0.05或 P <0.01);提高脾脏指数及脾细胞 ER 含量 (P <0.05或 P <0.01);改善胸腺组织病理变化。结论 Y FN 可以改善去势大鼠的免疫功能。Objective To investigate the effects of Yifuning soft gelatin capsules(YSGC)on immune function in ovariectomized (OVX) rats.Methods Fifty female mature Sprague-Dawley rats were randomized into 5 groups:normal control, model control, diethylstilbestrol tablets(DT)and YSGC(high-and low-dose). After 4-week treatment,the serum E2 and IL-2 levels were detected by radioimmunoassay. The estrogen receptor(ER)level in spleen were detected with method of radioligand receptor assay(RRA).The pathologic changes of thymus were observed under light microscope and the body weight,thymus index and spleen index were detected too.Results YSGC could obviously increase the serum levels of E2 and IL-2,increase spleen index and ER content in the spleen of OVX rats (P < 0.05 or P < 0.01).It also ameliorated the pathologic changes in the thymus. Conclusion YSGC can improve the immune function of OVX rats.

关 键 词：益妇宁软胶囊 更年期综合征 白细胞介素-2 雌激素受体 

分 类 号：R285.5[医药卫生—中药学]