急性肺损伤对体液免疫的影响及药物干预作用  

Effect of acute lung injury on humoral immunity and drug intervene

作　　者：曹慧玲[1] 王晓晖[1] 丁信军[1] 杨宁江[2] 

机构地区：[1]吉林军医学院附属医院，吉林市132013 [2]吉林军医学院，吉林市132013

出　　处：《第四军医大学吉林军医学院学报（86813X）》2000年第2期70-73,共4页Journal of Jilin Military Medical College Fourth Military Medical University

摘　　要：目的：旨在研究急性肺损伤(ALI)时H2受体阻滞剂对某些体液免疫功能的影响。方法：以油酸制作小白鼠ALI模型，观察地塞米松、肝素、西米替丁对其作用。结果：ALI早期H2受体阻滞剂对肺系数、补体及免疫球蛋白均无影响。结论：ALI早期H2受体阻滞剂对防治ALI及体液免疫无明显作用。Objective: To explore the effect of H2 receptor obstruction on humoral immuni-ty in acute lung injury(ALI) Methods: Preparing the AU models of mice with oleic acid, we observed the effect of dexamethasone, heparin and cimetidine on them. Results: In early ALI, H2 receptor obstruction had no effect on lung quotient, complement and immunoglobulin. Con-clusion In early AU, H2 receptor obstruction has no significant effect on humoral immunity and prevention of lung injury.

关 键 词：ALI H2受体阻滞剂 急性肺损伤 体液免疫 药物干预 早期 影响 结论 系数 目的 

分 类 号：R563[医药卫生—呼吸系统] G633[医药卫生—内科学]