肌酸激酶 MB 同功酶亚型 MB_2/MB_1比值在急性心肌梗塞的诊断意义  

Diagnostic Significance of Serum Isoforms of Creatine Kinase MB Isoenzyme (MB_2/MB_1 Ratio) in AMI

作　　者：孟庆义[1] 李天德[1] 杨兴生[1] 郭宝玲[1] 

机构地区：[1]中国人民解放军总医院心内科,博士生100853

出　　处：《天津医药》1993年第5期271-273,共3页Tianjin Medical Journal

摘　　要：本文采用琼脂凝胶电泳法动态观察22例急性心肌梗塞(AMI)血清肌酸激酶 MB同功酶亚型 MB_2/MB_1 比值的改变,并与23例心绞痛患者和20例健康人相比较。结果表明:健康人血清中 MB_1、MB_2 和 MB_2/MB_1 分别为1.2±0.9 U/L、0.9±0.8 U/L和0.80±0.25;与心绞痛组比较无显著性差异(P>0.05)。AMI 组血清 MB_2/MB_1 于梗塞后2～4小时升高,9小时左右达峰值,24小时后恢复正常。梗塞后6小时和6～12小时 MB_2/MB_1 比值的阳性率为46.2%(18/39例次)和83.3%(30/36例次),且梗塞6小时内入院的9例 AMI 血清 MB_2/MB_1 比值动态观察均为阳性。从而提示血清 CK-MB 亚型 MB_2/MB_1 比值是 AMI 中敏感而特异的诊断指标。Using an electrophoretic method,the changes in the catalytic activities of twoisoforms(MB_1,MB_2)of creatine kinase MB isoenzyme in serum of acute myocardialinfarction(AMI),angina and health people were assessed.The MB_1 activitity,MB_2activity and MB_2/MB_1 ratio in 20 healthy individuals were 1.2±0.9U/L,0.9±0.8U/Land 0.80±0.25 respectively.Similar results were obtained in 23 cases with angina.Among 22 patients with AMI,MB_2 activity and MB_2/MB_1 ratio began to increasewithin 4 hours after the onset of chest pain,reaching a peak at 9 hours and backto the baseline at 24 hours.The sensitivities in samples collected at 2～6,6～12 hoursafter onset of AMI were 46.2% and 83.3% for the MB_2/MB_1 ratio and 35.9% and97.2% for the MM_3/MM_1 ratio(P>0.05).These charaoteristics make the isoforms ofCK-MB an early,sensitive and specific indicator for AMI.

关 键 词：肌酸激酶 同功酶 心肌梗塞 诊断 

分 类 号：R542.220.4[医药卫生—心血管疾病]