天津地区乙肝病人和 HBsAg 携带者 HDV 感染的血清学研究  

Serologic Investigation of Patients with Hepatitis B and HDV Infection in HBsAg Carriers in Tianjin

作　　者：鲁春起 王淑惠[2] 王晓光[1] 张志宏[3] 鲁瑛 马凤阁[1] 王慧垣 来则民[1] 

机构地区：[1]天津医学院流行病学教研室,300070 [2]天津市传染病医院 [3]天津市静海县人民医院传染科 [4]天津市河西中医医院检验科

出　　处：《天津医药》1993年第6期343-345,共3页Tianjin Medical Journal

摘　　要：采用 ELISA 法对本地区113例 HB 病人和 HBsAg 携带者检测了抗-HDV。结果11例阳性,阳性率为9.73%。证实本地区不仅存在较高的 HDV 感染,并呈散发状态,且和 HB 的感染类型明显有关。其阳性率分别为;急性 HB_2.13%(1/47),慢性活动性 HB17.39%(4/23);慢性迁延性 HB33.33%(4/12);肝硬化12.50%(2/16);重症肝炎和 HBsAg 携带者未发现HDV 感染。由于慢性 HB 抗-HDV 阳性率明显高于急性 HB,提示 HDV 感染可能是急性 HB 病例慢性化发展的主要因素,也可能是 HB 病例难以治愈的重要原因。因此对 HDV 的感染不容忽视。建议对 HBV 易感者使用 HB 疫苗和避免接触 HB 病人及 HBsAg 携带者,以控制 HDV 的传播。One hundred and thirteen sera of HB cases and HBsAg carriers were detectedfor anti-HDV with ELISA.Of them 11 were positive,the positive rate was 9.73%(11/113).It indicated that there was HDV infection and it was associated with thetypes of HB.The positive rates were:2.13%(1/47)in acute HB;17.39%(4/23)inchronic active HB;33.33%(4/12)in chronic persistent HB;12.5%(2/16)in livercirrhosis.No HDV infection in HBsAg carriers was found.The positive rate of anti-HDV in chronic HB was higher than in acute HB,it was suggested that HDV infec-tion might be an importont factor of the chronicity of acute HB,and it was also theimportant reason for the intractability of HB.The use of HB vaccination for theHBV susceptibles and avoidance to contact with HB patients and HBsAg carrierswere recommended.

关 键 词：乙型肝炎病毒 丁型肝炎病毒 抗体 

分 类 号：R512.6[医药卫生—内科学]