慢性肺心病合并乳酸酸中毒的病因探讨  

Etiologic Evaluation of Chronic Cor Pulmonale with Lactic Acidosis

作　　者：王予思[1] 高庆珍[1] 

机构地区：[1]山西医学院第一附属医院内科,030001

出　　处：《天津医药》1993年第6期346-348,共3页Tianjin Medical Journal

摘　　要：对108例慢性肺心病合并酸中毒患者的血乳酸(L)、丙酮酸(P)含量测定和血气分析的结果显示,有高乳酸血症者37例(34.2%),乳酸酸中毒者10例(9.3%),表明血乳酸含量增高是肺心病合并代酸的重要原因。呼酸合并代酸组的血 L、P 含量和 L/P 比值显著增加,与呼酸组比较差异显著(P 值均<0.001)。同时血 L、P 含量增加与 PaO_2、SaO_2降低呈极显著负相关(r 分别为-0.92、-0.97,P<0.001),提示组织缺氧增强糖酵解过程致使血 L、P 含量增加是引起乳酸酸中毒的主要原因。The levels of lactate(L)and pyruvate(P)in blood,and blood gas analysis weredetermined in 108 chronic pulmonary heart diseases(CPHD)complicated with acidosis,in which there were 37 hyperlactatemia(34.2%)and 10 lactic acidosis(9.3%).Thesefindings showed that hyperlactatemia was a common pathogenesis of CPHD complica-ted metabolic acidosis.These levels of blood L,P and L/P ratio significantly increa-sed(in all P<0.001)in the group of CPHD complicated with respiratory acidosis.There was obviously negative correlation between blood L,P and PaO_2,SaO_2(r=-0.92,-0.97;P<0.001 respectively).It was suggested that tissue hypoxia and lowered oxygensatuation might play an important role in the pathogenesis of CPHD complicated withlactic acidosis.

关 键 词：肺心病 血气分析 乳酸 酸中毒 病因 

分 类 号：R541.5[医药卫生—心血管疾病]